A genetic study of dentin growth in the mandibular second and third molars of male mice

Jong Hyun Bae, Toshihide Matsumoto, Kazuaki Nonaka, Minoru Nakata

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Abstract

Although the influence of genetic and environmental factors on the completed crown size of mandibular molars in mice is well known, such influence on the growth process of the mandibular second and third molars of mice has not yet been clarified. The purpose of the present study is to examine the growth pattern of the dentinal formation and evaluate the relative contributions of both genetic and environmental factors to longitudinal dentin formation by the use of the partial diallel cross-genetic approach, the time-marking method and a computerized image measurement system. The following results were obtained: 1) the onset of dentinal formation in the second molar was on the 6-9th day after birth, while that of the third molar was on the 9-12th day after birth; 2) the best fitted growth curve of the dentinal formation for the first molar was the fifth order polynomial equation, while for the second molar the fourth order polynomial equation was best, and for the third molar the third order polynomial equation was best; 3) maternal effect strongly influenced the second and the third molar dentin growth at an early stage of postnatal growth. Thus, it could be concluded that the dentinal formation growth pattern differed among the three kinds of mouse molars while maternal environmental factors, in addition to genetic factors, played an important role in the mouse second and third molar dentin growth during the early stage of postnatal growth.

Original languageEnglish
Pages (from-to)137-147
Number of pages11
JournalJournal of Craniofacial Genetics and Developmental Biology
Volume16
Issue number3
Publication statusPublished - 1996

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All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Genetics

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