A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population

Masayuki Aoki, Ken Yamamoto, Shigekazu Ohyama, Yoshitaka Yamamura, Seiichi Takenoshita, Kokichi Sugano, Toshinari Minamoto, Masaki Kitajima, Haruhiko Sugimura, Shinya Shimada, Hirokazu Noshiro, Masahiro Hiratsuka, Motonori Sairenji, Itasu Ninomiya, Masahiko Yano, Katsuhiko Uesaka, Seiki Matsuno, Yoshihiko Maehara, Takashi Aikou, Takehiko Sasazuki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosomal regions, 1p32, 2q33-q35, 11p13-p14, and 21q21, for gastric cancer by linkage analysis. To identify genes involved in the disease, we performed a gene-based association analysis of 66 genes, located on 21p11-21q22, using 126 single nucleotide polymorphisms (SNPs) as genetic markers in 373 patients with 250 controls. We found a significant association of five SNPs in the stress70 protein chaperon family member STCH gene with gastric cancer, especially with the non-cardia localization subgroup (P = 0.0005-0.02, odds ratio = 1.44-1.72). Comparisons of haplotype frequency showed significant association between TTGGC haplotype and gastric cancer (P = 0.0001, odds ratio = 1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease.

Original languageEnglish
Pages (from-to)566-574
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume335
Issue number2
DOIs
Publication statusPublished - Sep 23 2005

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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