A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population

Masayuki Aoki, Ken Yamamoto, Shigekazu Ohyama, Yoshitaka Yamamura, Seiichi Takenoshita, Kokichi Sugano, Toshinari Minamoto, Masaki Kitajima, Haruhiko Sugimura, Shinya Shimada, Hirokazu Noshiro, Masahiro Hiratsuka, Motonori Sairenji, Itasu Ninomiya, Masahiko Yano, Katsuhiko Uesaka, Seiki Matsuno, Yoshihiko Maehara, Takashi Aikou, Takehiko Sasazuki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosomal regions, 1p32, 2q33-q35, 11p13-p14, and 21q21, for gastric cancer by linkage analysis. To identify genes involved in the disease, we performed a gene-based association analysis of 66 genes, located on 21p11-21q22, using 126 single nucleotide polymorphisms (SNPs) as genetic markers in 373 patients with 250 controls. We found a significant association of five SNPs in the stress70 protein chaperon family member STCH gene with gastric cancer, especially with the non-cardia localization subgroup (P = 0.0005-0.02, odds ratio = 1.44-1.72). Comparisons of haplotype frequency showed significant association between TTGGC haplotype and gastric cancer (P = 0.0001, odds ratio = 1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease.

Original languageEnglish
Pages (from-to)566-574
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume335
Issue number2
DOIs
Publication statusPublished - Sep 23 2005

Fingerprint

Gene encoding
Stomach Neoplasms
Genes
Population
Proteins
Polymorphism
Genetic Markers
Haplotypes
Single Nucleotide Polymorphism
Nucleotides
Odds Ratio
Disease Susceptibility
Linkage Disequilibrium
Alleles

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population. / Aoki, Masayuki; Yamamoto, Ken; Ohyama, Shigekazu; Yamamura, Yoshitaka; Takenoshita, Seiichi; Sugano, Kokichi; Minamoto, Toshinari; Kitajima, Masaki; Sugimura, Haruhiko; Shimada, Shinya; Noshiro, Hirokazu; Hiratsuka, Masahiro; Sairenji, Motonori; Ninomiya, Itasu; Yano, Masahiko; Uesaka, Katsuhiko; Matsuno, Seiki; Maehara, Yoshihiko; Aikou, Takashi; Sasazuki, Takehiko.

In: Biochemical and Biophysical Research Communications, Vol. 335, No. 2, 23.09.2005, p. 566-574.

Research output: Contribution to journalArticle

Aoki, M, Yamamoto, K, Ohyama, S, Yamamura, Y, Takenoshita, S, Sugano, K, Minamoto, T, Kitajima, M, Sugimura, H, Shimada, S, Noshiro, H, Hiratsuka, M, Sairenji, M, Ninomiya, I, Yano, M, Uesaka, K, Matsuno, S, Maehara, Y, Aikou, T & Sasazuki, T 2005, 'A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population', Biochemical and Biophysical Research Communications, vol. 335, no. 2, pp. 566-574. https://doi.org/10.1016/j.bbrc.2005.07.110
Aoki, Masayuki ; Yamamoto, Ken ; Ohyama, Shigekazu ; Yamamura, Yoshitaka ; Takenoshita, Seiichi ; Sugano, Kokichi ; Minamoto, Toshinari ; Kitajima, Masaki ; Sugimura, Haruhiko ; Shimada, Shinya ; Noshiro, Hirokazu ; Hiratsuka, Masahiro ; Sairenji, Motonori ; Ninomiya, Itasu ; Yano, Masahiko ; Uesaka, Katsuhiko ; Matsuno, Seiki ; Maehara, Yoshihiko ; Aikou, Takashi ; Sasazuki, Takehiko. / A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population. In: Biochemical and Biophysical Research Communications. 2005 ; Vol. 335, No. 2. pp. 566-574.
@article{7328068b28d8427e8e016028482b765f,
title = "A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population",
abstract = "Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosomal regions, 1p32, 2q33-q35, 11p13-p14, and 21q21, for gastric cancer by linkage analysis. To identify genes involved in the disease, we performed a gene-based association analysis of 66 genes, located on 21p11-21q22, using 126 single nucleotide polymorphisms (SNPs) as genetic markers in 373 patients with 250 controls. We found a significant association of five SNPs in the stress70 protein chaperon family member STCH gene with gastric cancer, especially with the non-cardia localization subgroup (P = 0.0005-0.02, odds ratio = 1.44-1.72). Comparisons of haplotype frequency showed significant association between TTGGC haplotype and gastric cancer (P = 0.0001, odds ratio = 1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease.",
author = "Masayuki Aoki and Ken Yamamoto and Shigekazu Ohyama and Yoshitaka Yamamura and Seiichi Takenoshita and Kokichi Sugano and Toshinari Minamoto and Masaki Kitajima and Haruhiko Sugimura and Shinya Shimada and Hirokazu Noshiro and Masahiro Hiratsuka and Motonori Sairenji and Itasu Ninomiya and Masahiko Yano and Katsuhiko Uesaka and Seiki Matsuno and Yoshihiko Maehara and Takashi Aikou and Takehiko Sasazuki",
year = "2005",
month = "9",
day = "23",
doi = "10.1016/j.bbrc.2005.07.110",
language = "English",
volume = "335",
pages = "566--574",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population

AU - Aoki, Masayuki

AU - Yamamoto, Ken

AU - Ohyama, Shigekazu

AU - Yamamura, Yoshitaka

AU - Takenoshita, Seiichi

AU - Sugano, Kokichi

AU - Minamoto, Toshinari

AU - Kitajima, Masaki

AU - Sugimura, Haruhiko

AU - Shimada, Shinya

AU - Noshiro, Hirokazu

AU - Hiratsuka, Masahiro

AU - Sairenji, Motonori

AU - Ninomiya, Itasu

AU - Yano, Masahiko

AU - Uesaka, Katsuhiko

AU - Matsuno, Seiki

AU - Maehara, Yoshihiko

AU - Aikou, Takashi

AU - Sasazuki, Takehiko

PY - 2005/9/23

Y1 - 2005/9/23

N2 - Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosomal regions, 1p32, 2q33-q35, 11p13-p14, and 21q21, for gastric cancer by linkage analysis. To identify genes involved in the disease, we performed a gene-based association analysis of 66 genes, located on 21p11-21q22, using 126 single nucleotide polymorphisms (SNPs) as genetic markers in 373 patients with 250 controls. We found a significant association of five SNPs in the stress70 protein chaperon family member STCH gene with gastric cancer, especially with the non-cardia localization subgroup (P = 0.0005-0.02, odds ratio = 1.44-1.72). Comparisons of haplotype frequency showed significant association between TTGGC haplotype and gastric cancer (P = 0.0001, odds ratio = 1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease.

AB - Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosomal regions, 1p32, 2q33-q35, 11p13-p14, and 21q21, for gastric cancer by linkage analysis. To identify genes involved in the disease, we performed a gene-based association analysis of 66 genes, located on 21p11-21q22, using 126 single nucleotide polymorphisms (SNPs) as genetic markers in 373 patients with 250 controls. We found a significant association of five SNPs in the stress70 protein chaperon family member STCH gene with gastric cancer, especially with the non-cardia localization subgroup (P = 0.0005-0.02, odds ratio = 1.44-1.72). Comparisons of haplotype frequency showed significant association between TTGGC haplotype and gastric cancer (P = 0.0001, odds ratio = 1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease.

UR - http://www.scopus.com/inward/record.url?scp=23744463987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744463987&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2005.07.110

DO - 10.1016/j.bbrc.2005.07.110

M3 - Article

C2 - 16087163

AN - SCOPUS:23744463987

VL - 335

SP - 566

EP - 574

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -