TY - JOUR
T1 - A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption
T2 - The J-MICC Study
AU - Nakagawa-Senda, Hiroko
AU - Hachiya, Tsuyoshi
AU - Shimizu, Atsushi
AU - Hosono, Satoyo
AU - Oze, Isao
AU - Watanabe, Miki
AU - Matsuo, Keitaro
AU - Ito, Hidemi
AU - Hara, Megumi
AU - Nishida, Yuichiro
AU - Endoh, Kaori
AU - Kuriki, Kiyonori
AU - Katsuura-Kamano, Sakurako
AU - Arisawa, Kokichi
AU - Nindita, Yora
AU - Ibusuki, Rie
AU - Suzuki, Sadao
AU - Hosono, Akihiro
AU - Mikami, Haruo
AU - Nakamura, Yohko
AU - Takashima, Naoyuki
AU - Nakamura, Yasuyuki
AU - Kuriyama, Nagato
AU - Ozaki, Etsuko
AU - Furusyo, Norihiro
AU - Ikezaki, Hiroaki
AU - Nakatochi, Masahiro
AU - Sasakabe, Tae
AU - Kawai, Sayo
AU - Okada, Rieko
AU - Hishida, Asahi
AU - Naito, Mariko
AU - Wakai, Kenji
AU - Momozawa, Yukihide
AU - Kubo, Michiaki
AU - Tanaka, Hideo
N1 - Funding Information:
We thank all the staff of the Laboratory for Genotyping Development, Center for the Integrative Medical Sciences, RIKEN, and the staff of the BioBank Japan project. This study was supported by Grants-in-Aid for Scientific Research for Priority Areas of Cancer (No. 17015018) and Innovative Areas (No. 221S0001) and by JSPS KAKENHI Grants (No. 16H06277 and 15H02524) from the Japanese Ministry of Education, Culture, Sports, Science and Technology. This work was also supported in part by a Grant-in-Aid from the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant (Grant-in-Aid for Young Scientists) Number 15K19236 and 17K15840. This study was supported in part by funding for the BioBank Japan Project from the Japan Agency for Medical Research and development since April 2015, and the Ministry of Education, Culture, Sports, Science and Technology from April 2003 to March 2015.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 × 10-6). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10-6), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10-16 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.
AB - Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 × 10-6). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10-6), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10-16 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.
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U2 - 10.1038/s41598-018-19914-w
DO - 10.1038/s41598-018-19914-w
M3 - Article
C2 - 29367735
AN - SCOPUS:85041020117
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 1493
ER -
