A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders: A retrospective survival analysis

Tetsuya Ando, Gen Komaki, Hiroki Nishimura, Tetsuro Naruo, Kenjiro Okabe, Keisuke Kawai, Masato Takii, Takakazu Oka, Naoki Kodama, Chiemi Nakamoto, Toshio Ishikawa, Mari Suzuki-Hotta, Kazunori Minatozaki, Chikara Yamaguchi, Aya Nishizono-Maher, Masaki Kono, Sohei Kajiwara, Hiroyuki Suematsu, Yuichiro Tomita, Shoichi EbanaYuri Okamoto, Katsutaro Nagata, Yoshikatsu Nakai, Masanori Koide, Nobuyuki Kobayashi, Nobuo Kurokawa, Toshihiko Nagata, Nobuo Kiriike, Yoshito Takenaka, Kiyohide Nagamine, Kazuyoshi Ookuma, Shiho Murata

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Abstract

Background: Patients with anorexia nervosa restricting type (AN-R) often develop bulimic symptoms and crossover to AN-binge eating/purging type (AN-BP), or to bulimia nervosa (BN). We have reported earlier that genetic variants of an orexigenic peptide ghrelin are associated with BN. Here, the relationship between a ghrelin gene variant and the rate of change from AN-R to other phenotypes of eating disorders (EDs) was investigated. MethodS: Participants were 165 patients with ED, initially diagnosed as AN-R. The dates of their AN-R onset and changes in diagnosis to other subtypes of ED were investigated retrospectively. Ghrelin gene 3056 T→C SNP (single nucleotide polymorphism) was genotyped. Probability and hazard ratios were analyzed using life table analysis and Cox's proportional hazard regression model, in which the starting point was the time of AN-R onset and the outcome events were the time of (i) onset of binge eating, that is, when patients changed to binge eating AN and BN and (ii) recovery of normal weight, that is, when patients changed to BN or remission. Results: Patients with the TT genotype at 3056 T→C had a higher probability and hazard ratio for recovery of normal weight. The ghrelin SNP was not related with the onset of binge eating. Conclusion: The 3056 T→C SNP of the ghrelin gene is related to the probability and the rate of recovery of normal body weight from restricting-type AN.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalPsychiatric Genetics
Volume20
Issue number4
DOIs
Publication statusPublished - Aug 1 2010

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Ghrelin
Anorexia Nervosa
Survival Analysis
Bulimia Nervosa
Bulimia
Phenotype
Single Nucleotide Polymorphism
Genes
Weights and Measures
Ideal Body Weight
Life Tables
Proportional Hazards Models
Genotype
Feeding and Eating Disorders
Peptides

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders : A retrospective survival analysis. / Ando, Tetsuya; Komaki, Gen; Nishimura, Hiroki; Naruo, Tetsuro; Okabe, Kenjiro; Kawai, Keisuke; Takii, Masato; Oka, Takakazu; Kodama, Naoki; Nakamoto, Chiemi; Ishikawa, Toshio; Suzuki-Hotta, Mari; Minatozaki, Kazunori; Yamaguchi, Chikara; Nishizono-Maher, Aya; Kono, Masaki; Kajiwara, Sohei; Suematsu, Hiroyuki; Tomita, Yuichiro; Ebana, Shoichi; Okamoto, Yuri; Nagata, Katsutaro; Nakai, Yoshikatsu; Koide, Masanori; Kobayashi, Nobuyuki; Kurokawa, Nobuo; Nagata, Toshihiko; Kiriike, Nobuo; Takenaka, Yoshito; Nagamine, Kiyohide; Ookuma, Kazuyoshi; Murata, Shiho.

In: Psychiatric Genetics, Vol. 20, No. 4, 01.08.2010, p. 153-159.

Research output: Contribution to journalArticle

Ando, T, Komaki, G, Nishimura, H, Naruo, T, Okabe, K, Kawai, K, Takii, M, Oka, T, Kodama, N, Nakamoto, C, Ishikawa, T, Suzuki-Hotta, M, Minatozaki, K, Yamaguchi, C, Nishizono-Maher, A, Kono, M, Kajiwara, S, Suematsu, H, Tomita, Y, Ebana, S, Okamoto, Y, Nagata, K, Nakai, Y, Koide, M, Kobayashi, N, Kurokawa, N, Nagata, T, Kiriike, N, Takenaka, Y, Nagamine, K, Ookuma, K & Murata, S 2010, 'A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders: A retrospective survival analysis', Psychiatric Genetics, vol. 20, no. 4, pp. 153-159. https://doi.org/10.1097/YPG.0b013e32833a1f0e
Ando, Tetsuya ; Komaki, Gen ; Nishimura, Hiroki ; Naruo, Tetsuro ; Okabe, Kenjiro ; Kawai, Keisuke ; Takii, Masato ; Oka, Takakazu ; Kodama, Naoki ; Nakamoto, Chiemi ; Ishikawa, Toshio ; Suzuki-Hotta, Mari ; Minatozaki, Kazunori ; Yamaguchi, Chikara ; Nishizono-Maher, Aya ; Kono, Masaki ; Kajiwara, Sohei ; Suematsu, Hiroyuki ; Tomita, Yuichiro ; Ebana, Shoichi ; Okamoto, Yuri ; Nagata, Katsutaro ; Nakai, Yoshikatsu ; Koide, Masanori ; Kobayashi, Nobuyuki ; Kurokawa, Nobuo ; Nagata, Toshihiko ; Kiriike, Nobuo ; Takenaka, Yoshito ; Nagamine, Kiyohide ; Ookuma, Kazuyoshi ; Murata, Shiho. / A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders : A retrospective survival analysis. In: Psychiatric Genetics. 2010 ; Vol. 20, No. 4. pp. 153-159.
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abstract = "Background: Patients with anorexia nervosa restricting type (AN-R) often develop bulimic symptoms and crossover to AN-binge eating/purging type (AN-BP), or to bulimia nervosa (BN). We have reported earlier that genetic variants of an orexigenic peptide ghrelin are associated with BN. Here, the relationship between a ghrelin gene variant and the rate of change from AN-R to other phenotypes of eating disorders (EDs) was investigated. MethodS: Participants were 165 patients with ED, initially diagnosed as AN-R. The dates of their AN-R onset and changes in diagnosis to other subtypes of ED were investigated retrospectively. Ghrelin gene 3056 T→C SNP (single nucleotide polymorphism) was genotyped. Probability and hazard ratios were analyzed using life table analysis and Cox's proportional hazard regression model, in which the starting point was the time of AN-R onset and the outcome events were the time of (i) onset of binge eating, that is, when patients changed to binge eating AN and BN and (ii) recovery of normal weight, that is, when patients changed to BN or remission. Results: Patients with the TT genotype at 3056 T→C had a higher probability and hazard ratio for recovery of normal weight. The ghrelin SNP was not related with the onset of binge eating. Conclusion: The 3056 T→C SNP of the ghrelin gene is related to the probability and the rate of recovery of normal body weight from restricting-type AN.",
author = "Tetsuya Ando and Gen Komaki and Hiroki Nishimura and Tetsuro Naruo and Kenjiro Okabe and Keisuke Kawai and Masato Takii and Takakazu Oka and Naoki Kodama and Chiemi Nakamoto and Toshio Ishikawa and Mari Suzuki-Hotta and Kazunori Minatozaki and Chikara Yamaguchi and Aya Nishizono-Maher and Masaki Kono and Sohei Kajiwara and Hiroyuki Suematsu and Yuichiro Tomita and Shoichi Ebana and Yuri Okamoto and Katsutaro Nagata and Yoshikatsu Nakai and Masanori Koide and Nobuyuki Kobayashi and Nobuo Kurokawa and Toshihiko Nagata and Nobuo Kiriike and Yoshito Takenaka and Kiyohide Nagamine and Kazuyoshi Ookuma and Shiho Murata",
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TY - JOUR

T1 - A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders

T2 - A retrospective survival analysis

AU - Ando, Tetsuya

AU - Komaki, Gen

AU - Nishimura, Hiroki

AU - Naruo, Tetsuro

AU - Okabe, Kenjiro

AU - Kawai, Keisuke

AU - Takii, Masato

AU - Oka, Takakazu

AU - Kodama, Naoki

AU - Nakamoto, Chiemi

AU - Ishikawa, Toshio

AU - Suzuki-Hotta, Mari

AU - Minatozaki, Kazunori

AU - Yamaguchi, Chikara

AU - Nishizono-Maher, Aya

AU - Kono, Masaki

AU - Kajiwara, Sohei

AU - Suematsu, Hiroyuki

AU - Tomita, Yuichiro

AU - Ebana, Shoichi

AU - Okamoto, Yuri

AU - Nagata, Katsutaro

AU - Nakai, Yoshikatsu

AU - Koide, Masanori

AU - Kobayashi, Nobuyuki

AU - Kurokawa, Nobuo

AU - Nagata, Toshihiko

AU - Kiriike, Nobuo

AU - Takenaka, Yoshito

AU - Nagamine, Kiyohide

AU - Ookuma, Kazuyoshi

AU - Murata, Shiho

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: Patients with anorexia nervosa restricting type (AN-R) often develop bulimic symptoms and crossover to AN-binge eating/purging type (AN-BP), or to bulimia nervosa (BN). We have reported earlier that genetic variants of an orexigenic peptide ghrelin are associated with BN. Here, the relationship between a ghrelin gene variant and the rate of change from AN-R to other phenotypes of eating disorders (EDs) was investigated. MethodS: Participants were 165 patients with ED, initially diagnosed as AN-R. The dates of their AN-R onset and changes in diagnosis to other subtypes of ED were investigated retrospectively. Ghrelin gene 3056 T→C SNP (single nucleotide polymorphism) was genotyped. Probability and hazard ratios were analyzed using life table analysis and Cox's proportional hazard regression model, in which the starting point was the time of AN-R onset and the outcome events were the time of (i) onset of binge eating, that is, when patients changed to binge eating AN and BN and (ii) recovery of normal weight, that is, when patients changed to BN or remission. Results: Patients with the TT genotype at 3056 T→C had a higher probability and hazard ratio for recovery of normal weight. The ghrelin SNP was not related with the onset of binge eating. Conclusion: The 3056 T→C SNP of the ghrelin gene is related to the probability and the rate of recovery of normal body weight from restricting-type AN.

AB - Background: Patients with anorexia nervosa restricting type (AN-R) often develop bulimic symptoms and crossover to AN-binge eating/purging type (AN-BP), or to bulimia nervosa (BN). We have reported earlier that genetic variants of an orexigenic peptide ghrelin are associated with BN. Here, the relationship between a ghrelin gene variant and the rate of change from AN-R to other phenotypes of eating disorders (EDs) was investigated. MethodS: Participants were 165 patients with ED, initially diagnosed as AN-R. The dates of their AN-R onset and changes in diagnosis to other subtypes of ED were investigated retrospectively. Ghrelin gene 3056 T→C SNP (single nucleotide polymorphism) was genotyped. Probability and hazard ratios were analyzed using life table analysis and Cox's proportional hazard regression model, in which the starting point was the time of AN-R onset and the outcome events were the time of (i) onset of binge eating, that is, when patients changed to binge eating AN and BN and (ii) recovery of normal weight, that is, when patients changed to BN or remission. Results: Patients with the TT genotype at 3056 T→C had a higher probability and hazard ratio for recovery of normal weight. The ghrelin SNP was not related with the onset of binge eating. Conclusion: The 3056 T→C SNP of the ghrelin gene is related to the probability and the rate of recovery of normal body weight from restricting-type AN.

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