The golden oyster mushroom Pleurotus citrinopileatus is a popular edible mushroom with multifunctional biological activities, but there are a limited number of previous studies on its chemical composition. This is the first report of the isolation of glucosylceramide with antimicrobial activity from the fruiting body of this mushroom. This compound was identified as 1-O-β-D-glucopyranosyl-(2S,3R,4E,8E)-2-[(2R)-2-hydroxyhexadecanoylamino]-9-methyl-4,8-octadecadiene-1,3-diol. The IC 50 value of this compound for the growth of Escherichia coli and Staphylococcus aureus was 275. 1 μM (200 μg/ml) and 323. 2 μM (235 μg/ml), respectively.
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