Abstract
The P, V, and C proteins of measles virus are encoded in overlapping reading frames of the P gene, which makes it difficult to analyze the functions of the individual proteins in the context of virus infection. We established a system to analyze the C protein independently from the P and V proteins by placing its gene in an additional transcription unit between the H and L genes. Analyses with this system indicated that a highly attenuated Edmonston lineage vaccine strain encodes a fully functional C protein, and the P and/or V protein is involved in the attenuated phenotype.
| Original language | English |
|---|---|
| Pages (from-to) | 11996-12001 |
| Number of pages | 6 |
| Journal | Journal of virology |
| Volume | 83 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - Nov 1 2009 |
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All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Insect Science
- Virology
Cite this
A highly attenuated measles virus vaccine strain encodes a fully functional C protein. / Nakatsu, Yuichiro; Takeda, Makoto; Iwasaki, Masaharu; Yanagi, Yusuke.
In: Journal of virology, Vol. 83, No. 22, 01.11.2009, p. 11996-12001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A highly attenuated measles virus vaccine strain encodes a fully functional C protein
AU - Nakatsu, Yuichiro
AU - Takeda, Makoto
AU - Iwasaki, Masaharu
AU - Yanagi, Yusuke
PY - 2009/11/1
Y1 - 2009/11/1
N2 - The P, V, and C proteins of measles virus are encoded in overlapping reading frames of the P gene, which makes it difficult to analyze the functions of the individual proteins in the context of virus infection. We established a system to analyze the C protein independently from the P and V proteins by placing its gene in an additional transcription unit between the H and L genes. Analyses with this system indicated that a highly attenuated Edmonston lineage vaccine strain encodes a fully functional C protein, and the P and/or V protein is involved in the attenuated phenotype.
AB - The P, V, and C proteins of measles virus are encoded in overlapping reading frames of the P gene, which makes it difficult to analyze the functions of the individual proteins in the context of virus infection. We established a system to analyze the C protein independently from the P and V proteins by placing its gene in an additional transcription unit between the H and L genes. Analyses with this system indicated that a highly attenuated Edmonston lineage vaccine strain encodes a fully functional C protein, and the P and/or V protein is involved in the attenuated phenotype.
UR - http://www.scopus.com/inward/record.url?scp=70350327329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350327329&partnerID=8YFLogxK
U2 - 10.1128/JVI.00791-09
DO - 10.1128/JVI.00791-09
M3 - Article
C2 - 19726523
AN - SCOPUS:70350327329
VL - 83
SP - 11996
EP - 12001
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 22
ER -