A highly attenuated measles virus vaccine strain encodes a fully functional C protein

Yuichiro Nakatsu, Makoto Takeda, Masaharu Iwasaki, Yusuke Yanagi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The P, V, and C proteins of measles virus are encoded in overlapping reading frames of the P gene, which makes it difficult to analyze the functions of the individual proteins in the context of virus infection. We established a system to analyze the C protein independently from the P and V proteins by placing its gene in an additional transcription unit between the H and L genes. Analyses with this system indicated that a highly attenuated Edmonston lineage vaccine strain encodes a fully functional C protein, and the P and/or V protein is involved in the attenuated phenotype.

Original languageEnglish
Pages (from-to)11996-12001
Number of pages6
JournalJournal of virology
Volume83
Issue number22
DOIs
Publication statusPublished - Nov 1 2009

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Measles virus
Measles Vaccine
Attenuated Vaccines
Protein C
vaccines
Genes
Reading Frames
Proteins
proteins
Virus Diseases
Vaccines
Phenotype
genes
transcription (genetics)
phenotype
viruses
infection

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

A highly attenuated measles virus vaccine strain encodes a fully functional C protein. / Nakatsu, Yuichiro; Takeda, Makoto; Iwasaki, Masaharu; Yanagi, Yusuke.

In: Journal of virology, Vol. 83, No. 22, 01.11.2009, p. 11996-12001.

Research output: Contribution to journalArticle

Nakatsu, Yuichiro ; Takeda, Makoto ; Iwasaki, Masaharu ; Yanagi, Yusuke. / A highly attenuated measles virus vaccine strain encodes a fully functional C protein. In: Journal of virology. 2009 ; Vol. 83, No. 22. pp. 11996-12001.
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