A highly attenuated measles virus vaccine strain encodes a fully functional C protein

Yuichiro Nakatsu, Makoto Takeda, Masaharu Iwasaki, Yusuke Yanagi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The P, V, and C proteins of measles virus are encoded in overlapping reading frames of the P gene, which makes it difficult to analyze the functions of the individual proteins in the context of virus infection. We established a system to analyze the C protein independently from the P and V proteins by placing its gene in an additional transcription unit between the H and L genes. Analyses with this system indicated that a highly attenuated Edmonston lineage vaccine strain encodes a fully functional C protein, and the P and/or V protein is involved in the attenuated phenotype.

Original languageEnglish
Pages (from-to)11996-12001
Number of pages6
JournalJournal of virology
Volume83
Issue number22
DOIs
Publication statusPublished - Nov 2009

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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