Abstract
The title reactions of sterically crowded 2-oxazolidone derivatives with achiral aldehydes in the presence of zinc dust were found to give various 2,3-syn-aldols as major products (at most, 2,3-syn:2,3-anti=98:2). While a 2,3-syn-3,4-syn-aldol could be similarly produced in a highly stereoselective manner, application of the explored reaction to asymmetric synthesis of optically active 2,3-syn-aldols was found to be unpromising.
Original language | English |
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Pages (from-to) | 6629-6632 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 28 |
Issue number | 52 |
DOIs | |
Publication status | Published - Jan 1 1987 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry