A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism

Makoto Takeda, Maino Tahara, Takao Hashiguchi, Takeshi A. Sato, Fumiaki Jinnouchi, Shoko Ueki, Shinji Ohno, Yusuke Yanagi

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Measles virus (MV) propagates mainly in lymphoid organs throughout the body and produces syncytia by using signaling lymphocyte activation molecule (SLAM) as a receptor. MV also spreads in SLAM-negative epithelial tissues by unknown mechanisms. Ubiquitously expressed CD46 functions as another receptor for vaccine strains of MV but not for wild-type strains. We here show that MV grows and produces syncytia efficiently in a human lung adenocarcinoma cell line via a SLAM- and CD46-independent mechanism using a novel receptor-binding site on the hemagglutinin protein. This infection model could advance our understanding of MV infection of SLAM-negative epithelial cells and tissues.

Original languageEnglish
Pages (from-to)12091-12096
Number of pages6
JournalJournal of virology
Volume81
Issue number21
DOIs
Publication statusPublished - Nov 2007

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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