A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism

Makoto Takeda, Maino Tahara, Takao Hashiguchi, Takeshi A. Sato, Fumiaki Jinnouchi, Shoko Ueki, Shinji Ohno, Yusuke Yanagi

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Measles virus (MV) propagates mainly in lymphoid organs throughout the body and produces syncytia by using signaling lymphocyte activation molecule (SLAM) as a receptor. MV also spreads in SLAM-negative epithelial tissues by unknown mechanisms. Ubiquitously expressed CD46 functions as another receptor for vaccine strains of MV but not for wild-type strains. We here show that MV grows and produces syncytia efficiently in a human lung adenocarcinoma cell line via a SLAM- and CD46-independent mechanism using a novel receptor-binding site on the hemagglutinin protein. This infection model could advance our understanding of MV infection of SLAM-negative epithelial cells and tissues.

Original languageEnglish
Pages (from-to)12091-12096
Number of pages6
JournalJournal of virology
Volume81
Issue number21
DOIs
Publication statusPublished - Nov 1 2007

Fingerprint

Measles virus
giant cells
Giant Cells
lymphocyte proliferation
Lymphocyte Activation
carcinoma
lungs
cell lines
Carcinoma
Cell Line
Lung
Growth
receptors
epithelium
Epithelium
Hemagglutinins
Virus Diseases
hemagglutinins
adenocarcinoma
infection

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism. / Takeda, Makoto; Tahara, Maino; Hashiguchi, Takao; Sato, Takeshi A.; Jinnouchi, Fumiaki; Ueki, Shoko; Ohno, Shinji; Yanagi, Yusuke.

In: Journal of virology, Vol. 81, No. 21, 01.11.2007, p. 12091-12096.

Research output: Contribution to journalArticle

Takeda, Makoto ; Tahara, Maino ; Hashiguchi, Takao ; Sato, Takeshi A. ; Jinnouchi, Fumiaki ; Ueki, Shoko ; Ohno, Shinji ; Yanagi, Yusuke. / A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism. In: Journal of virology. 2007 ; Vol. 81, No. 21. pp. 12091-12096.
@article{ee3aa33d117949a0ab575fb8b1536d54,
title = "A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism",
abstract = "Measles virus (MV) propagates mainly in lymphoid organs throughout the body and produces syncytia by using signaling lymphocyte activation molecule (SLAM) as a receptor. MV also spreads in SLAM-negative epithelial tissues by unknown mechanisms. Ubiquitously expressed CD46 functions as another receptor for vaccine strains of MV but not for wild-type strains. We here show that MV grows and produces syncytia efficiently in a human lung adenocarcinoma cell line via a SLAM- and CD46-independent mechanism using a novel receptor-binding site on the hemagglutinin protein. This infection model could advance our understanding of MV infection of SLAM-negative epithelial cells and tissues.",
author = "Makoto Takeda and Maino Tahara and Takao Hashiguchi and Sato, {Takeshi A.} and Fumiaki Jinnouchi and Shoko Ueki and Shinji Ohno and Yusuke Yanagi",
year = "2007",
month = "11",
day = "1",
doi = "10.1128/JVI.01264-07",
language = "English",
volume = "81",
pages = "12091--12096",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "21",

}

TY - JOUR

T1 - A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism

AU - Takeda, Makoto

AU - Tahara, Maino

AU - Hashiguchi, Takao

AU - Sato, Takeshi A.

AU - Jinnouchi, Fumiaki

AU - Ueki, Shoko

AU - Ohno, Shinji

AU - Yanagi, Yusuke

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Measles virus (MV) propagates mainly in lymphoid organs throughout the body and produces syncytia by using signaling lymphocyte activation molecule (SLAM) as a receptor. MV also spreads in SLAM-negative epithelial tissues by unknown mechanisms. Ubiquitously expressed CD46 functions as another receptor for vaccine strains of MV but not for wild-type strains. We here show that MV grows and produces syncytia efficiently in a human lung adenocarcinoma cell line via a SLAM- and CD46-independent mechanism using a novel receptor-binding site on the hemagglutinin protein. This infection model could advance our understanding of MV infection of SLAM-negative epithelial cells and tissues.

AB - Measles virus (MV) propagates mainly in lymphoid organs throughout the body and produces syncytia by using signaling lymphocyte activation molecule (SLAM) as a receptor. MV also spreads in SLAM-negative epithelial tissues by unknown mechanisms. Ubiquitously expressed CD46 functions as another receptor for vaccine strains of MV but not for wild-type strains. We here show that MV grows and produces syncytia efficiently in a human lung adenocarcinoma cell line via a SLAM- and CD46-independent mechanism using a novel receptor-binding site on the hemagglutinin protein. This infection model could advance our understanding of MV infection of SLAM-negative epithelial cells and tissues.

UR - http://www.scopus.com/inward/record.url?scp=35448948794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35448948794&partnerID=8YFLogxK

U2 - 10.1128/JVI.01264-07

DO - 10.1128/JVI.01264-07

M3 - Article

C2 - 17715217

AN - SCOPUS:35448948794

VL - 81

SP - 12091

EP - 12096

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 21

ER -