A human T cell‐specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein‐tyrosine kinases

Yasuhiro Koga, Nicolette Caccia, Barry Toyonaga, Rosanne Spolski, Yusuke Yanagi, Yasunobu Yoshikai, Tak W. Mak

    Research output: Contribution to journalArticle

    58 Citations (Scopus)

    Abstract

    We report here the isolation of a human T cell‐specific cDNA clone (YT16) that encodes a protein with extensive homology to a family of transformation and proliferation‐related protein‐tyrosine kinases (PTK). The message size of YT16 is 2.2 kb and it encodes a protein of 507 amino acids with a mol. mass of 57136 Daltons. The deduced protein sequence has an overall homology of about 50% to the viral oncogene products of src and yes. Around the PTK catalytic domain, the homologies increase to 70–80% between the deduced protein sequence of YT16 and those of the PTK viral oncogenes. Of special interest is the extensive homology between the deduced protein sequence of YT16 and that of a recently reported murine B and T lymphocyte‐specific PTK, lskT. It is possible that YT16 either encodes the human homologue of this murine gene, or a protein with similar function(s) in T cells.

    Original languageEnglish
    Pages (from-to)1643-1646
    Number of pages4
    JournalEuropean Journal of Immunology
    Volume16
    Issue number12
    DOIs
    Publication statusPublished - Jan 1 1986

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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