A hypertriglyceridemic state increases high sensitivity C-reactive protein of Japanese men with normal glucose tolerance

Kyoko Okada, Norihiro Furusyo, Murata Masayuki, Yasunori Sawayama, Mosaburo Kainuma, Jun Hayashi

Research output: Contribution to journalArticle

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Abstract

Both fasting and postprandial hypertriglyceridemia have been identified as risk markers for cardiovascular disease. High-sensitivity C-reactive protein (hs-CRP), known to independently predict future cardiovascular disease, has also been reported to be a direct participant in the progression of atherosclerosis. We evaluated whether or not fasting and/or postprandial hypertriglyceridemia influence hs-CRP of men with normal glucose tolerance. According to the triglyceride (TG) level, measured before and 1 and 2 h after a meal tolerance test, subjects were classified into a normotriglyceridemic (NTG) group (n = 86), a postprandial hypertriglyceridemia (PHTG) group (n = 50), or a fasting hypertriglyceridemia (FHTG) group (n = 53). Hs-CRP and HOMA-R were significantly higher in the FHTG group than in the other groups (P<0.01). The PHTG group had higher hs-CRP than the NTG group (P<0.05). No significant differences in age, BMI, LDL cholesterol, or carotid intima-media thickness were found in comparison of the three groups. Multivariate linear regression analysis showed that the area under the TG curve (AUC-TG), HbA1c, and BMI were independently correlated with hs-CRP (P<0.001, P = 0.016, P = 0.032, respectively). Our data suggests that a hypertriglyceridemic state is associated with hs-CRP irrespective of BMI, LDL-C, and HDL-C, indicating that hs-CRP might represent chronic inflammation induced by hypertriglyceridemia in Japanese men with normal glucose tolerance.

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalEndocrine
Volume41
Issue number1
DOIs
Publication statusPublished - Feb 1 2012

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Hypertriglyceridemia
C-Reactive Protein
Glucose
Fasting
Triglycerides
Area Under Curve
Cardiovascular Diseases
Carotid Intima-Media Thickness
LDL Cholesterol
Meals
Linear Models
Atherosclerosis
Regression Analysis
Inflammation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

A hypertriglyceridemic state increases high sensitivity C-reactive protein of Japanese men with normal glucose tolerance. / Okada, Kyoko; Furusyo, Norihiro; Masayuki, Murata; Sawayama, Yasunori; Kainuma, Mosaburo; Hayashi, Jun.

In: Endocrine, Vol. 41, No. 1, 01.02.2012, p. 96-102.

Research output: Contribution to journalArticle

Okada, Kyoko ; Furusyo, Norihiro ; Masayuki, Murata ; Sawayama, Yasunori ; Kainuma, Mosaburo ; Hayashi, Jun. / A hypertriglyceridemic state increases high sensitivity C-reactive protein of Japanese men with normal glucose tolerance. In: Endocrine. 2012 ; Vol. 41, No. 1. pp. 96-102.
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