A Japanese case of severe refractory adult Still's disease: serum interleukin-18 is a possible marker of the response to low-dose cyclosporin A therapy.

Yasunori Sawayama, Shigeki Nabeshima, Hiroaki Taniai, Norihiro Furusyo, Seizaburo Kashiwagi, Jun Hayashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 22-year-old man was admitted to our hospital with a high fever, fatigue, mild arthritis, and bilateral pleural effusions. Laboratory tests revealed a high ESR, leukocytosis, high serum C-reactive protein level, and high serum ferritin level. Various antibiotics had been given by a local hospital with no response. He was diagnosed as having severe refractory adult Still's disease and was subsequently treated with high-dose steroid therapy and low-dose cyclosporin A. The serum interleukin-18 level was monitored throughout treatment and was found to be a potentially useful marker of disease activity as well as of the response to cyclosporin A therapy.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume93
Issue number9
Publication statusPublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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