A Japanese case of severe refractory adult Still's disease

serum interleukin-18 is a possible marker of the response to low-dose cyclosporin A therapy.

Yasunori Sawayama, Shigeki Nabeshima, Hiroaki Taniai, Norihiro Furusyo, Seizaburo Kashiwagi, Jun Hayashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 22-year-old man was admitted to our hospital with a high fever, fatigue, mild arthritis, and bilateral pleural effusions. Laboratory tests revealed a high ESR, leukocytosis, high serum C-reactive protein level, and high serum ferritin level. Various antibiotics had been given by a local hospital with no response. He was diagnosed as having severe refractory adult Still's disease and was subsequently treated with high-dose steroid therapy and low-dose cyclosporin A. The serum interleukin-18 level was monitored throughout treatment and was found to be a potentially useful marker of disease activity as well as of the response to cyclosporin A therapy.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume93
Issue number9
Publication statusPublished - Jan 1 2002

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Interleukin-18
Cyclosporine
Serum
Leukocytosis
Pleural Effusion
Ferritins
C-Reactive Protein
Arthritis
Fatigue
Blood Proteins
Fever
Therapeutics
Steroids
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

A Japanese case of severe refractory adult Still's disease : serum interleukin-18 is a possible marker of the response to low-dose cyclosporin A therapy. / Sawayama, Yasunori; Nabeshima, Shigeki; Taniai, Hiroaki; Furusyo, Norihiro; Kashiwagi, Seizaburo; Hayashi, Jun.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 93, No. 9, 01.01.2002, p. 189-195.

Research output: Contribution to journalArticle

Sawayama, Yasunori ; Nabeshima, Shigeki ; Taniai, Hiroaki ; Furusyo, Norihiro ; Kashiwagi, Seizaburo ; Hayashi, Jun. / A Japanese case of severe refractory adult Still's disease : serum interleukin-18 is a possible marker of the response to low-dose cyclosporin A therapy. In: Fukuoka igaku zasshi = Hukuoka acta medica. 2002 ; Vol. 93, No. 9. pp. 189-195.
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