A long-term survival case of hepatocellular carcinoma with portal vein and inferior vena cava tumor thrombi

Vasuji Hashimoto, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori, Hiroaki Nagano

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Abstract

We report a case of advanced hepatocellular carcinoma (HCC) successfully treated by hepatic arterial infusion of 5-fluo-rouracil (5-FU) combined with systemic administration of interferon (IFN)-a and trans-arterial infusion (TAI) therapy of cisplatin (CDDP). A case was a 60-year-old man who had right upper abdominal pain and back pain. The abdominal CT revealed an early enhanced lesion in the posterior segment of the liver with portal vein and inferior vena caval tumor thrombi and multiple intrahepatic metastases. Tumor markers were elevated, AFP 2,480ng/mL, PIVKA-n 31,900mAU/mL. The patient underwent 4 courses of IFN-α5-FU combination therapy and 8 times of TAI therapy of CDDP. After these therapies, tumors in the liver disappeared and tumor markers returned to the normal range. The patient is alive more than 58 months after the initial treatment. This case suggests that some patients with advanced HCC with tumor thrombus can get a long-term survival when intrahepatic lesions are controlled by various therapies including IFN-α5-FU combination therapy.

Original languageEnglish
Pages (from-to)2693-2695
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number12
Publication statusPublished - 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Oncology
  • Cancer Research

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    Hashimoto, V., Wada, H., Kobayashi, S., Marubashi, S., Eguchi, H., Takeda, Y., Tanemura, M., Umeshita, K., Doki, Y., Mori, M., & Nagano, H. (2010). A long-term survival case of hepatocellular carcinoma with portal vein and inferior vena cava tumor thrombi. Japanese Journal of Cancer and Chemotherapy, 37(12), 2693-2695.