Abstract
Results: During the follow-up period, 134 subjects experienced cardiovascular events. The incidence of cardiovascular disease across the ABI values was significantly different (p＜0.001). After adjusting for confounding factors, namely age, sex, systolic blood pressure, use of anti-hypertensive drugs, diabetes, total cholesterol, high-density lipoprotein cholesterol, obesity, smoking, alcohol intake and regular exercise, individuals with a low ABI were at 2.40-fold (95% confidence interval [CI] 1.14-5.06) greater risk of cardiovascular disease and 4.13-fold (95% CI 1.62-10.55) greater risk of coronary heart disease.
Conclusions: Our findings suggest that individuals with an ABI of ≤ 0.90 have an increased risk of cardiovascular events, independent from traditional risk factors, in the general Japanese population.
Aim: Peripheral artery disease (PAD), defined as a decreased ankle brachial index (ABI), is a risk factor for cardiovascular disease; however, few studies have assessed the relationship between a low ABI and cardiovascular risks in Asian populations. We herein examined the relationship between the ABI and the development of cardiovascular disease in a Japanese community.
Methods: A total of 2,954 community-dwelling Japanese individuals without prior cardiovascular disease ≥ 40 years of age were followed up for an average of 7.1 years. The subjects’ ABIs were categorized into the three groups: low (≤ 0.90), borderline (0.91-0.99) and normal (1.00-1.40). We estimated the relationship between the ABI and cardiovascular risk using a Cox proportional hazards model.
| Original language | English |
|---|---|
| Pages (from-to) | 966-973 |
| Number of pages | 8 |
| Journal | Journal of atherosclerosis and thrombosis |
| Volume | 21 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jan 1 2014 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Cardiology and Cardiovascular Medicine
- Biochemistry, medical
Cite this
A low ankle brachial index is associated with an increased risk of cardiovascular disease : The hisayama study. / Kojima, Iwao; Ninomiya, Toshiharu; Hata, Jun; Fukuhara, Masayo; Hirakawa, Yoichiro; Mukai, Naoko; Yoshida, Daigo; Kitazono, Takanari; Kiyohara, Yutaka.
In: Journal of atherosclerosis and thrombosis, Vol. 21, No. 9, 01.01.2014, p. 966-973.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A low ankle brachial index is associated with an increased risk of cardiovascular disease
T2 - The hisayama study
AU - Kojima, Iwao
AU - Ninomiya, Toshiharu
AU - Hata, Jun
AU - Fukuhara, Masayo
AU - Hirakawa, Yoichiro
AU - Mukai, Naoko
AU - Yoshida, Daigo
AU - Kitazono, Takanari
AU - Kiyohara, Yutaka
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Results: During the follow-up period, 134 subjects experienced cardiovascular events. The incidence of cardiovascular disease across the ABI values was significantly different (p＜0.001). After adjusting for confounding factors, namely age, sex, systolic blood pressure, use of anti-hypertensive drugs, diabetes, total cholesterol, high-density lipoprotein cholesterol, obesity, smoking, alcohol intake and regular exercise, individuals with a low ABI were at 2.40-fold (95% confidence interval [CI] 1.14-5.06) greater risk of cardiovascular disease and 4.13-fold (95% CI 1.62-10.55) greater risk of coronary heart disease.Conclusions: Our findings suggest that individuals with an ABI of ≤ 0.90 have an increased risk of cardiovascular events, independent from traditional risk factors, in the general Japanese population.Aim: Peripheral artery disease (PAD), defined as a decreased ankle brachial index (ABI), is a risk factor for cardiovascular disease; however, few studies have assessed the relationship between a low ABI and cardiovascular risks in Asian populations. We herein examined the relationship between the ABI and the development of cardiovascular disease in a Japanese community.Methods: A total of 2,954 community-dwelling Japanese individuals without prior cardiovascular disease ≥ 40 years of age were followed up for an average of 7.1 years. The subjects’ ABIs were categorized into the three groups: low (≤ 0.90), borderline (0.91-0.99) and normal (1.00-1.40). We estimated the relationship between the ABI and cardiovascular risk using a Cox proportional hazards model.
AB - Results: During the follow-up period, 134 subjects experienced cardiovascular events. The incidence of cardiovascular disease across the ABI values was significantly different (p＜0.001). After adjusting for confounding factors, namely age, sex, systolic blood pressure, use of anti-hypertensive drugs, diabetes, total cholesterol, high-density lipoprotein cholesterol, obesity, smoking, alcohol intake and regular exercise, individuals with a low ABI were at 2.40-fold (95% confidence interval [CI] 1.14-5.06) greater risk of cardiovascular disease and 4.13-fold (95% CI 1.62-10.55) greater risk of coronary heart disease.Conclusions: Our findings suggest that individuals with an ABI of ≤ 0.90 have an increased risk of cardiovascular events, independent from traditional risk factors, in the general Japanese population.Aim: Peripheral artery disease (PAD), defined as a decreased ankle brachial index (ABI), is a risk factor for cardiovascular disease; however, few studies have assessed the relationship between a low ABI and cardiovascular risks in Asian populations. We herein examined the relationship between the ABI and the development of cardiovascular disease in a Japanese community.Methods: A total of 2,954 community-dwelling Japanese individuals without prior cardiovascular disease ≥ 40 years of age were followed up for an average of 7.1 years. The subjects’ ABIs were categorized into the three groups: low (≤ 0.90), borderline (0.91-0.99) and normal (1.00-1.40). We estimated the relationship between the ABI and cardiovascular risk using a Cox proportional hazards model.
UR - http://www.scopus.com/inward/record.url?scp=84907506388&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907506388&partnerID=8YFLogxK
U2 - 10.5551/jat.22608
DO - 10.5551/jat.22608
M3 - Article
C2 - 24727729
AN - SCOPUS:84907506388
VL - 21
SP - 966
EP - 973
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
SN - 1340-3478
IS - 9
ER -