A mathematical design of vector vaccine against autoimmune disease

Shingo Iwami, Yasuhiro Takeuchi, Kentaro Iwamoto, Yoshimi Naruo, Masahiro Yasukawa

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Viruses have been implicated in the initiation, progression, and exacerbation of several human autoimmune diseases. Evidence also exists that viruses can protect against autoimmune disease. Several proposed mechanisms explain the viral effects. One mechanism is "molecular mimicry" which represents a shared immunologic epitope with a microbe and the host. We consider, using a simple mathematical model, whether and how a viral infection with molecular mimicry can be beneficial or detrimental for autoimmune disease. Furthermore, we consider the possibility of development of a vector therapeutic vaccine that can relieve autoimmune disease symptoms. Our findings demonstrate that vaccine therapy success necessitates (i) appropriate immune response function, (ii) appropriate affinities with self and non-self antigen, and (iii) a replicative vector vaccine. Moreover, the model shows that the viral infection can cause autoimmune relapses.

Original languageEnglish
Pages (from-to)382-392
Number of pages11
JournalJournal of Theoretical Biology
Volume256
Issue number3
DOIs
Publication statusPublished - Feb 7 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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