A model for the circadian rhythm of cyanobacteria that maintains oscillation without gene expression

Gen Kurosawa, Kazuyuki Aihara, Yoh Iwasa

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

An intriguing property of the cyanobacterial circadian clock is that endogenous rhythm persists when protein abundances are kept constant either in the presence of translation and transcription inhibitors or in the constant dark condition. Here we propose a regulatory mechanism of KaiC phosphorylation for the generation of circadian oscillations in cyanobacteria. In the model, clock proteins KaiA and KaiB are assumed to have multiple states, regulating the KaiC phosphorylation process. The model can explain 1), the sustained oscillation of gene expression and protein abundance when the expression of the kaiBC gene is regulated by KaiC protein, and 2), the sustained oscillation of phosphorylated KaiC when transcription and translation processes are inhibited and total protein abundance is fixed. Results of this work suggest that KaiA and KaiB strengthen the nonlinearity of KaiC phosphorylation, thereby promoting the circadian rhythm in cyanobacteria.

Original languageEnglish
Pages (from-to)2015-2023
Number of pages9
JournalBiophysical Journal
Volume91
Issue number6
DOIs
Publication statusPublished - Jan 1 2006

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Cyanobacteria
Circadian Rhythm
Gene Expression
Phosphorylation
Proteins
Circadian Clocks

All Science Journal Classification (ASJC) codes

  • Biophysics

Cite this

A model for the circadian rhythm of cyanobacteria that maintains oscillation without gene expression. / Kurosawa, Gen; Aihara, Kazuyuki; Iwasa, Yoh.

In: Biophysical Journal, Vol. 91, No. 6, 01.01.2006, p. 2015-2023.

Research output: Contribution to journalArticle

Kurosawa, Gen ; Aihara, Kazuyuki ; Iwasa, Yoh. / A model for the circadian rhythm of cyanobacteria that maintains oscillation without gene expression. In: Biophysical Journal. 2006 ; Vol. 91, No. 6. pp. 2015-2023.
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