A Model of Transcriptional Activation of DNA by Loosening of Chromatin Structure

Yuko T. Sato, Daisuke Asai, Keiko Terada, Jeong Hun Kang, Takeshi Mori, Takuro Niidome, Hideki Nakashima, Yoshiki Katayama

Research output: Contribution to journalArticlepeer-review

Abstract

As a model of transcriptional activation of DNA by loosening of chromatin structure, we have developed a polymeric complex of plasmid DNA and a cationic polymer (SRC-Y) bearing peptide moieties that are phosphorylatable by p60c-Src. After phosphorylation, the diffusion constant of DAPIintercalated plasmid DNA in SRC-Y/DNA particles increased, concomitantly with initiation of transcription, meaning that the access of preinitiation complex, which recruits RNA polymerase II to promoter sequences, to chromatin-packaged DNA for transcriptional initiation is governed by DNA strand mobility.

Original languageEnglish
Pages (from-to)1109-1112
Number of pages4
JournalChemistry Letters
Volume51
Issue number12
DOIs
Publication statusPublished - Dec 2022

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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