A multiple primary carcinoma consisting of leukoplakia and SCC: A case report with p53 mutation analysis

Nur Mohammad Monsur Hassan, Mitsuhiro Tada, Masanobu Shindoh, Jun Ichi Hamada, Haruhiko Kashiwazaki, Tsuyoshi Shimo, Yuichi Ashikaga, Yutaka Yamazaki, Akira Sasaki, Tetsuya Moriuchi, Nobuo Inoue

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3 Citations (Scopus)

Abstract

Patients with an oral squamous cell carcinoma (OSCC) often develop multiple malignant lesions. This report examined whether individual tumours developed in a patient show the same genetic alteration, such as p53 mutations. This case study describes three SCCs and three leukoplakias which developed simultaneously in a single 67-year-old Japanese man. A p53 mutation was detected in two of the three SCCs and one of the three leukoplakias. One SCC had a missense mutation at codon 285 (GAG>AAG, Glu>Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT>CAT, Arg>His). This case showed that individual oral tumours may have different genetic changes even when they develop in a single patient. Therefore, this report provided strong evidence that in cases of multiple tumours it is necessary to design tailor-made therapies for each individual tumour rather than a single standardised therapy for all multiple tumours.

Original languageEnglish
Pages (from-to)4773-4778
Number of pages6
JournalAnticancer Research
Volume30
Issue number11
Publication statusPublished - Nov 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Hassan, N. M. M., Tada, M., Shindoh, M., Hamada, J. I., Kashiwazaki, H., Shimo, T., Ashikaga, Y., Yamazaki, Y., Sasaki, A., Moriuchi, T., & Inoue, N. (2010). A multiple primary carcinoma consisting of leukoplakia and SCC: A case report with p53 mutation analysis. Anticancer Research, 30(11), 4773-4778.