A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

Riki Toita, Masaharu Murata, Kana Abe, Sayoko Narahara, Jing Shu Piao, Jeong Hun Kang, Makoto Hashizume

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.

Original languageEnglish
Pages (from-to)7442-7444
Number of pages3
JournalChemical Communications
Volume49
Issue number67
DOIs
Publication statusPublished - Aug 28 2013

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Doxorubicin
Cells
Proteins
Hepatocytes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells. / Toita, Riki; Murata, Masaharu; Abe, Kana; Narahara, Sayoko; Piao, Jing Shu; Kang, Jeong Hun; Hashizume, Makoto.

In: Chemical Communications, Vol. 49, No. 67, 28.08.2013, p. 7442-7444.

Research output: Contribution to journalArticle

Toita, R, Murata, M, Abe, K, Narahara, S, Piao, JS, Kang, JH & Hashizume, M 2013, 'A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells', Chemical Communications, vol. 49, no. 67, pp. 7442-7444. https://doi.org/10.1039/c3cc44508a
Toita, Riki ; Murata, Masaharu ; Abe, Kana ; Narahara, Sayoko ; Piao, Jing Shu ; Kang, Jeong Hun ; Hashizume, Makoto. / A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells. In: Chemical Communications. 2013 ; Vol. 49, No. 67. pp. 7442-7444.
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