A nationwide cross-sectional study on congenital heart diseases and symptoms of sleep-disordered breathing among japanese down’s syndrome people

Hiroyuki Sawatari, Akiko Chishaki, Mari Nishizaka, Fumio Matsuoka, Chikara Yoshimura, Hiromi Kuroda, Anita Rahmawati, Nobuko Hashiguchi, Mami Miyazono, Junji Ono, Tomoko Ohkusa, Shin Ichi Ando

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective It is well known that people with Down’s syndrome (DS) frequently complicate with congenital heart diseases (CHDs). Patients with heart diseases often have sleep-disordered breathing as a co-morbidity (SDB) which worsens the heart diseases. However, the relationship between SDB and CHDs in DS people has not yet been fully elucidated. The aim of this study was to establish the association between SDB and CHDs in DS people using data from a large nationwide questionnaire survey in Japan. Methods We conducted a cross-sectional questionnaire survey of a randomly selected sample of 2,000 DS people and their caregivers throughout Japan to examine the associations between observed signs of SDB and CHDs in DS people. The questionnaire included the presence of SDB symptoms (snoring, apnea, arousal, nocturia, and napping) and CHDs (the presence and types of CHDs). Results Of the 1,222 replies received from the caregivers, 650 reported complications of some type of CHDs. The observed apnea tended to be higher among DS people with CHDs than those without CHDs (OR=1.28, 95% CI=0.97-1.70, p=0.09). DS people with tetralogy of Fallot reported significantly more frequent apnea than those without CHDs (OR=3.10, 95% CI=1.36-7.05, p<0.01). Conclusion SDB prevailed among DS people with severe CHDs, such as tetralogy of Fallot. Careful attention to the signs of SDB in such patients may lead to earlier clinical intervention removing the vicious cycle between SDB and CHDs.

Original languageEnglish
Pages (from-to)1003-1008
Number of pages6
JournalInternal Medicine
Volume54
Issue number9
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Sleep Apnea Syndromes
Down Syndrome
Heart Diseases
Cross-Sectional Studies
Apnea
Tetralogy of Fallot
Caregivers
Japan
Nocturia
Snoring
Arousal

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

A nationwide cross-sectional study on congenital heart diseases and symptoms of sleep-disordered breathing among japanese down’s syndrome people. / Sawatari, Hiroyuki; Chishaki, Akiko; Nishizaka, Mari; Matsuoka, Fumio; Yoshimura, Chikara; Kuroda, Hiromi; Rahmawati, Anita; Hashiguchi, Nobuko; Miyazono, Mami; Ono, Junji; Ohkusa, Tomoko; Ando, Shin Ichi.

In: Internal Medicine, Vol. 54, No. 9, 01.01.2015, p. 1003-1008.

Research output: Contribution to journalArticle

Sawatari, H, Chishaki, A, Nishizaka, M, Matsuoka, F, Yoshimura, C, Kuroda, H, Rahmawati, A, Hashiguchi, N, Miyazono, M, Ono, J, Ohkusa, T & Ando, SI 2015, 'A nationwide cross-sectional study on congenital heart diseases and symptoms of sleep-disordered breathing among japanese down’s syndrome people', Internal Medicine, vol. 54, no. 9, pp. 1003-1008. https://doi.org/10.2169/internalmedicine.54.3989
Sawatari, Hiroyuki ; Chishaki, Akiko ; Nishizaka, Mari ; Matsuoka, Fumio ; Yoshimura, Chikara ; Kuroda, Hiromi ; Rahmawati, Anita ; Hashiguchi, Nobuko ; Miyazono, Mami ; Ono, Junji ; Ohkusa, Tomoko ; Ando, Shin Ichi. / A nationwide cross-sectional study on congenital heart diseases and symptoms of sleep-disordered breathing among japanese down’s syndrome people. In: Internal Medicine. 2015 ; Vol. 54, No. 9. pp. 1003-1008.
@article{e9d385c9f8ca4605801d7ce595ae3447,
title = "A nationwide cross-sectional study on congenital heart diseases and symptoms of sleep-disordered breathing among japanese down’s syndrome people",
abstract = "Objective It is well known that people with Down’s syndrome (DS) frequently complicate with congenital heart diseases (CHDs). Patients with heart diseases often have sleep-disordered breathing as a co-morbidity (SDB) which worsens the heart diseases. However, the relationship between SDB and CHDs in DS people has not yet been fully elucidated. The aim of this study was to establish the association between SDB and CHDs in DS people using data from a large nationwide questionnaire survey in Japan. Methods We conducted a cross-sectional questionnaire survey of a randomly selected sample of 2,000 DS people and their caregivers throughout Japan to examine the associations between observed signs of SDB and CHDs in DS people. The questionnaire included the presence of SDB symptoms (snoring, apnea, arousal, nocturia, and napping) and CHDs (the presence and types of CHDs). Results Of the 1,222 replies received from the caregivers, 650 reported complications of some type of CHDs. The observed apnea tended to be higher among DS people with CHDs than those without CHDs (OR=1.28, 95{\%} CI=0.97-1.70, p=0.09). DS people with tetralogy of Fallot reported significantly more frequent apnea than those without CHDs (OR=3.10, 95{\%} CI=1.36-7.05, p<0.01). Conclusion SDB prevailed among DS people with severe CHDs, such as tetralogy of Fallot. Careful attention to the signs of SDB in such patients may lead to earlier clinical intervention removing the vicious cycle between SDB and CHDs.",
author = "Hiroyuki Sawatari and Akiko Chishaki and Mari Nishizaka and Fumio Matsuoka and Chikara Yoshimura and Hiromi Kuroda and Anita Rahmawati and Nobuko Hashiguchi and Mami Miyazono and Junji Ono and Tomoko Ohkusa and Ando, {Shin Ichi}",
year = "2015",
month = "1",
day = "1",
doi = "10.2169/internalmedicine.54.3989",
language = "English",
volume = "54",
pages = "1003--1008",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "9",

}

TY - JOUR

T1 - A nationwide cross-sectional study on congenital heart diseases and symptoms of sleep-disordered breathing among japanese down’s syndrome people

AU - Sawatari, Hiroyuki

AU - Chishaki, Akiko

AU - Nishizaka, Mari

AU - Matsuoka, Fumio

AU - Yoshimura, Chikara

AU - Kuroda, Hiromi

AU - Rahmawati, Anita

AU - Hashiguchi, Nobuko

AU - Miyazono, Mami

AU - Ono, Junji

AU - Ohkusa, Tomoko

AU - Ando, Shin Ichi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective It is well known that people with Down’s syndrome (DS) frequently complicate with congenital heart diseases (CHDs). Patients with heart diseases often have sleep-disordered breathing as a co-morbidity (SDB) which worsens the heart diseases. However, the relationship between SDB and CHDs in DS people has not yet been fully elucidated. The aim of this study was to establish the association between SDB and CHDs in DS people using data from a large nationwide questionnaire survey in Japan. Methods We conducted a cross-sectional questionnaire survey of a randomly selected sample of 2,000 DS people and their caregivers throughout Japan to examine the associations between observed signs of SDB and CHDs in DS people. The questionnaire included the presence of SDB symptoms (snoring, apnea, arousal, nocturia, and napping) and CHDs (the presence and types of CHDs). Results Of the 1,222 replies received from the caregivers, 650 reported complications of some type of CHDs. The observed apnea tended to be higher among DS people with CHDs than those without CHDs (OR=1.28, 95% CI=0.97-1.70, p=0.09). DS people with tetralogy of Fallot reported significantly more frequent apnea than those without CHDs (OR=3.10, 95% CI=1.36-7.05, p<0.01). Conclusion SDB prevailed among DS people with severe CHDs, such as tetralogy of Fallot. Careful attention to the signs of SDB in such patients may lead to earlier clinical intervention removing the vicious cycle between SDB and CHDs.

AB - Objective It is well known that people with Down’s syndrome (DS) frequently complicate with congenital heart diseases (CHDs). Patients with heart diseases often have sleep-disordered breathing as a co-morbidity (SDB) which worsens the heart diseases. However, the relationship between SDB and CHDs in DS people has not yet been fully elucidated. The aim of this study was to establish the association between SDB and CHDs in DS people using data from a large nationwide questionnaire survey in Japan. Methods We conducted a cross-sectional questionnaire survey of a randomly selected sample of 2,000 DS people and their caregivers throughout Japan to examine the associations between observed signs of SDB and CHDs in DS people. The questionnaire included the presence of SDB symptoms (snoring, apnea, arousal, nocturia, and napping) and CHDs (the presence and types of CHDs). Results Of the 1,222 replies received from the caregivers, 650 reported complications of some type of CHDs. The observed apnea tended to be higher among DS people with CHDs than those without CHDs (OR=1.28, 95% CI=0.97-1.70, p=0.09). DS people with tetralogy of Fallot reported significantly more frequent apnea than those without CHDs (OR=3.10, 95% CI=1.36-7.05, p<0.01). Conclusion SDB prevailed among DS people with severe CHDs, such as tetralogy of Fallot. Careful attention to the signs of SDB in such patients may lead to earlier clinical intervention removing the vicious cycle between SDB and CHDs.

UR - http://www.scopus.com/inward/record.url?scp=84928952881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928952881&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.54.3989

DO - 10.2169/internalmedicine.54.3989

M3 - Article

C2 - 25948338

AN - SCOPUS:84928952881

VL - 54

SP - 1003

EP - 1008

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 9

ER -