A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases

Etsuro Nanishi, Takayuki Hoshina, Hidetoshi Takada, masataka ishimura, Hisanori Nishio, Takahiro Uehara, Yumi Mizuno, Shunji Hasegawa, Shoichi Ohga, Masayoshi Nagao, Maiko Igarashi, Shuhei Yajima, Yoshio Kusumoto, Noriko Onishi, Yoji Sasahara, Takahiro Yasumi, Toshio Heike, Toshiro Hara, Chie Kobayashi, Takashi Ishige & 30 others Kanako Kudo, Kyouko Suzuki, Shohei Ogata, Masako Kikuchi, Yachiyo Kurihara, Ryo Niiya, Tomohiro Katsuta, Yutaka Saikawa, Hisao Yoshida, Yuko Ishizaki, Akira Hayakawa, Toshihiko Shirakawa, Toshihiko Mori, Yutaka Suzuki, Hideo Tsuda, Tomoko Sato, Tomoko Waragai, Satoru Kumaki, Osamu Komiyama, Masumi Seto, Ryo Kadoya, Noriko Ohbuchi, Hiroko Kozan, Hiroyuki Shimizu, Tomoyuki Imagawa, Yoshiyuki Yamada, Takuya Hara, Takuro Ohno, Eiji Ota, Hiroyuki Toda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives Patients with primary immunodeficiency diseases (PID) are highly susceptible to various microorganisms. However, no population-based studies have been performed among common viral pathogens, such as respiratory syncytial virus (RSV), rotavirus (RV), varicella-zoster virus (VZV) and influenza virus (IV). The objective of this study was to reveal the clinical burden of these four infections among PID patients in Japan. Methods We conducted a nationwide survey by sending questionnaires to 898 hospitals with pediatric departments throughout Japan. Results Nine hundred ten PID patients from 621 hospitals were registered (response rate: 69.2%). Fifty-four of the patients were hospitalized due to these viral infections. The durations of hospitalization due to RSV and RV infections differed significantly in the PID patients with and without cellular immunodeficiency (12.0 vs 6.5 days, p = 0.041; and 14.0 vs 6.0 days, p = 0.031, respectively). There was no significant difference in the duration of hospitalization in PID patients with and without cellular immunodeficiency who were hospitalized with IV infections (7.3 vs 6.1 days, p = 0.53). Conclusions Special attention should be paid to PID patients with compromised cellular immunity who present with RSV and RV infection due to their high risk for severe disease.

Original languageEnglish
Pages (from-to)358-368
Number of pages11
JournalJournal of Infection
Volume73
Issue number4
DOIs
Publication statusPublished - Oct 1 2016

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Virus Diseases
Rotavirus Infections
Respiratory Syncytial Virus Infections
Orthomyxoviridae
Japan
Hospitalization
Pediatric Hospitals
Human Herpesvirus 3
Respiratory Syncytial Viruses
Rotavirus
Surveys and Questionnaires
Cellular Immunity
Infection
Population

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases. / Nanishi, Etsuro; Hoshina, Takayuki; Takada, Hidetoshi; ishimura, masataka; Nishio, Hisanori; Uehara, Takahiro; Mizuno, Yumi; Hasegawa, Shunji; Ohga, Shoichi; Nagao, Masayoshi; Igarashi, Maiko; Yajima, Shuhei; Kusumoto, Yoshio; Onishi, Noriko; Sasahara, Yoji; Yasumi, Takahiro; Heike, Toshio; Hara, Toshiro; Kobayashi, Chie; Ishige, Takashi; Kudo, Kanako; Suzuki, Kyouko; Ogata, Shohei; Kikuchi, Masako; Kurihara, Yachiyo; Niiya, Ryo; Katsuta, Tomohiro; Saikawa, Yutaka; Yoshida, Hisao; Ishizaki, Yuko; Hayakawa, Akira; Shirakawa, Toshihiko; Mori, Toshihiko; Suzuki, Yutaka; Tsuda, Hideo; Sato, Tomoko; Waragai, Tomoko; Kumaki, Satoru; Komiyama, Osamu; Seto, Masumi; Kadoya, Ryo; Ohbuchi, Noriko; Kozan, Hiroko; Shimizu, Hiroyuki; Imagawa, Tomoyuki; Yamada, Yoshiyuki; Hara, Takuya; Ohno, Takuro; Ota, Eiji; Toda, Hiroyuki.

In: Journal of Infection, Vol. 73, No. 4, 01.10.2016, p. 358-368.

Research output: Contribution to journalArticle

Nanishi, E, Hoshina, T, Takada, H, ishimura, M, Nishio, H, Uehara, T, Mizuno, Y, Hasegawa, S, Ohga, S, Nagao, M, Igarashi, M, Yajima, S, Kusumoto, Y, Onishi, N, Sasahara, Y, Yasumi, T, Heike, T, Hara, T, Kobayashi, C, Ishige, T, Kudo, K, Suzuki, K, Ogata, S, Kikuchi, M, Kurihara, Y, Niiya, R, Katsuta, T, Saikawa, Y, Yoshida, H, Ishizaki, Y, Hayakawa, A, Shirakawa, T, Mori, T, Suzuki, Y, Tsuda, H, Sato, T, Waragai, T, Kumaki, S, Komiyama, O, Seto, M, Kadoya, R, Ohbuchi, N, Kozan, H, Shimizu, H, Imagawa, T, Yamada, Y, Hara, T, Ohno, T, Ota, E & Toda, H 2016, 'A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases', Journal of Infection, vol. 73, no. 4, pp. 358-368. https://doi.org/10.1016/j.jinf.2016.07.018
Nanishi, Etsuro ; Hoshina, Takayuki ; Takada, Hidetoshi ; ishimura, masataka ; Nishio, Hisanori ; Uehara, Takahiro ; Mizuno, Yumi ; Hasegawa, Shunji ; Ohga, Shoichi ; Nagao, Masayoshi ; Igarashi, Maiko ; Yajima, Shuhei ; Kusumoto, Yoshio ; Onishi, Noriko ; Sasahara, Yoji ; Yasumi, Takahiro ; Heike, Toshio ; Hara, Toshiro ; Kobayashi, Chie ; Ishige, Takashi ; Kudo, Kanako ; Suzuki, Kyouko ; Ogata, Shohei ; Kikuchi, Masako ; Kurihara, Yachiyo ; Niiya, Ryo ; Katsuta, Tomohiro ; Saikawa, Yutaka ; Yoshida, Hisao ; Ishizaki, Yuko ; Hayakawa, Akira ; Shirakawa, Toshihiko ; Mori, Toshihiko ; Suzuki, Yutaka ; Tsuda, Hideo ; Sato, Tomoko ; Waragai, Tomoko ; Kumaki, Satoru ; Komiyama, Osamu ; Seto, Masumi ; Kadoya, Ryo ; Ohbuchi, Noriko ; Kozan, Hiroko ; Shimizu, Hiroyuki ; Imagawa, Tomoyuki ; Yamada, Yoshiyuki ; Hara, Takuya ; Ohno, Takuro ; Ota, Eiji ; Toda, Hiroyuki. / A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases. In: Journal of Infection. 2016 ; Vol. 73, No. 4. pp. 358-368.
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abstract = "Objectives Patients with primary immunodeficiency diseases (PID) are highly susceptible to various microorganisms. However, no population-based studies have been performed among common viral pathogens, such as respiratory syncytial virus (RSV), rotavirus (RV), varicella-zoster virus (VZV) and influenza virus (IV). The objective of this study was to reveal the clinical burden of these four infections among PID patients in Japan. Methods We conducted a nationwide survey by sending questionnaires to 898 hospitals with pediatric departments throughout Japan. Results Nine hundred ten PID patients from 621 hospitals were registered (response rate: 69.2{\%}). Fifty-four of the patients were hospitalized due to these viral infections. The durations of hospitalization due to RSV and RV infections differed significantly in the PID patients with and without cellular immunodeficiency (12.0 vs 6.5 days, p = 0.041; and 14.0 vs 6.0 days, p = 0.031, respectively). There was no significant difference in the duration of hospitalization in PID patients with and without cellular immunodeficiency who were hospitalized with IV infections (7.3 vs 6.1 days, p = 0.53). Conclusions Special attention should be paid to PID patients with compromised cellular immunity who present with RSV and RV infection due to their high risk for severe disease.",
author = "Etsuro Nanishi and Takayuki Hoshina and Hidetoshi Takada and masataka ishimura and Hisanori Nishio and Takahiro Uehara and Yumi Mizuno and Shunji Hasegawa and Shoichi Ohga and Masayoshi Nagao and Maiko Igarashi and Shuhei Yajima and Yoshio Kusumoto and Noriko Onishi and Yoji Sasahara and Takahiro Yasumi and Toshio Heike and Toshiro Hara and Chie Kobayashi and Takashi Ishige and Kanako Kudo and Kyouko Suzuki and Shohei Ogata and Masako Kikuchi and Yachiyo Kurihara and Ryo Niiya and Tomohiro Katsuta and Yutaka Saikawa and Hisao Yoshida and Yuko Ishizaki and Akira Hayakawa and Toshihiko Shirakawa and Toshihiko Mori and Yutaka Suzuki and Hideo Tsuda and Tomoko Sato and Tomoko Waragai and Satoru Kumaki and Osamu Komiyama and Masumi Seto and Ryo Kadoya and Noriko Ohbuchi and Hiroko Kozan and Hiroyuki Shimizu and Tomoyuki Imagawa and Yoshiyuki Yamada and Takuya Hara and Takuro Ohno and Eiji Ota and Hiroyuki Toda",
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T1 - A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases

AU - Nanishi, Etsuro

AU - Hoshina, Takayuki

AU - Takada, Hidetoshi

AU - ishimura, masataka

AU - Nishio, Hisanori

AU - Uehara, Takahiro

AU - Mizuno, Yumi

AU - Hasegawa, Shunji

AU - Ohga, Shoichi

AU - Nagao, Masayoshi

AU - Igarashi, Maiko

AU - Yajima, Shuhei

AU - Kusumoto, Yoshio

AU - Onishi, Noriko

AU - Sasahara, Yoji

AU - Yasumi, Takahiro

AU - Heike, Toshio

AU - Hara, Toshiro

AU - Kobayashi, Chie

AU - Ishige, Takashi

AU - Kudo, Kanako

AU - Suzuki, Kyouko

AU - Ogata, Shohei

AU - Kikuchi, Masako

AU - Kurihara, Yachiyo

AU - Niiya, Ryo

AU - Katsuta, Tomohiro

AU - Saikawa, Yutaka

AU - Yoshida, Hisao

AU - Ishizaki, Yuko

AU - Hayakawa, Akira

AU - Shirakawa, Toshihiko

AU - Mori, Toshihiko

AU - Suzuki, Yutaka

AU - Tsuda, Hideo

AU - Sato, Tomoko

AU - Waragai, Tomoko

AU - Kumaki, Satoru

AU - Komiyama, Osamu

AU - Seto, Masumi

AU - Kadoya, Ryo

AU - Ohbuchi, Noriko

AU - Kozan, Hiroko

AU - Shimizu, Hiroyuki

AU - Imagawa, Tomoyuki

AU - Yamada, Yoshiyuki

AU - Hara, Takuya

AU - Ohno, Takuro

AU - Ota, Eiji

AU - Toda, Hiroyuki

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Objectives Patients with primary immunodeficiency diseases (PID) are highly susceptible to various microorganisms. However, no population-based studies have been performed among common viral pathogens, such as respiratory syncytial virus (RSV), rotavirus (RV), varicella-zoster virus (VZV) and influenza virus (IV). The objective of this study was to reveal the clinical burden of these four infections among PID patients in Japan. Methods We conducted a nationwide survey by sending questionnaires to 898 hospitals with pediatric departments throughout Japan. Results Nine hundred ten PID patients from 621 hospitals were registered (response rate: 69.2%). Fifty-four of the patients were hospitalized due to these viral infections. The durations of hospitalization due to RSV and RV infections differed significantly in the PID patients with and without cellular immunodeficiency (12.0 vs 6.5 days, p = 0.041; and 14.0 vs 6.0 days, p = 0.031, respectively). There was no significant difference in the duration of hospitalization in PID patients with and without cellular immunodeficiency who were hospitalized with IV infections (7.3 vs 6.1 days, p = 0.53). Conclusions Special attention should be paid to PID patients with compromised cellular immunity who present with RSV and RV infection due to their high risk for severe disease.

AB - Objectives Patients with primary immunodeficiency diseases (PID) are highly susceptible to various microorganisms. However, no population-based studies have been performed among common viral pathogens, such as respiratory syncytial virus (RSV), rotavirus (RV), varicella-zoster virus (VZV) and influenza virus (IV). The objective of this study was to reveal the clinical burden of these four infections among PID patients in Japan. Methods We conducted a nationwide survey by sending questionnaires to 898 hospitals with pediatric departments throughout Japan. Results Nine hundred ten PID patients from 621 hospitals were registered (response rate: 69.2%). Fifty-four of the patients were hospitalized due to these viral infections. The durations of hospitalization due to RSV and RV infections differed significantly in the PID patients with and without cellular immunodeficiency (12.0 vs 6.5 days, p = 0.041; and 14.0 vs 6.0 days, p = 0.031, respectively). There was no significant difference in the duration of hospitalization in PID patients with and without cellular immunodeficiency who were hospitalized with IV infections (7.3 vs 6.1 days, p = 0.53). Conclusions Special attention should be paid to PID patients with compromised cellular immunity who present with RSV and RV infection due to their high risk for severe disease.

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JO - Journal of Infection

JF - Journal of Infection

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