A nationwide survey of hepatitis E virus infection and chronic hepatitis in heart and kidney transplant recipients in Japan

Yohei Owada; Yukio Oshiro; Yuki Inagaki; Hiroshi Harada; Nobuhiro Fujiyama; Naoki Kawagishi; Takashi Yagisawa; Joichi Usui; Naotake Akutsu; Yoshihiro Itabashi; Kazuhide Saito; Yoshihiko Watarai; Naotsugu Ichimaru; Ryoichi Imamura; Miyaji Kyakuno; Kentaro Ide; Yuichi Shibuya; Yasuhiro Okabe; Minoru Ono; Konosuke Sasaki; Akira Shiose; Kazumasa Yamagishi; Hiroshi Ohnishi; Shigeo Nagashima; Masaharu Takahashi; Kenji Yuzawa; Hiroaki Okamoto; Nobuhiro Ohkohchi

doi:10.1097/TP.0000000000002801

A nationwide survey of hepatitis E virus infection and chronic hepatitis in heart and kidney transplant recipients in Japan

Yohei Owada, Yukio Oshiro, Yuki Inagaki, Hiroshi Harada, Nobuhiro Fujiyama, Naoki Kawagishi, Takashi Yagisawa, Joichi Usui, Naotake Akutsu, Yoshihiro Itabashi, Kazuhide Saito, Yoshihiko Watarai, Naotsugu Ichimaru, Ryoichi Imamura, Miyaji Kyakuno, Kentaro Ide, Yuichi Shibuya, Yasuhiro Okabe, Minoru Ono, Konosuke SasakiAkira Shiose, Kazumasa Yamagishi, Hiroshi Ohnishi, Shigeo Nagashima, Masaharu Takahashi, Kenji Yuzawa, Hiroaki Okamoto, Nobuhiro Ohkohchi

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Abstract

Background: Recently, chronic hepatitis E has been reported in solid organ transplant (SOT) recipients in European countries. Previously, we clarified the prevalence of hepatitis E virus (HEV) infection in Japanese liver transplant recipients and identified 2 chronic hepatitis E patients infected by blood transfusion. However, the rate of HEV infection in recipients of SOTs other than liver in Japan remains unclear, so we conducted a nationwide survey to clarify the prevalence of chronic HEV infection in Japanese heart and kidney transplant recipients. Methods. A total of 99 heart and 2526 kidney transplant recipients in 17 hospitals in Japan were examined for the presence of the IgG class of anti-HEV antibodies as well as for serum HEV RNA. Results: The prevalence of anti-HEV IgG among heart and kidney transplant recipients was 7.07% (7/99) and 4.08% (103/2526), respectively. One heart transplant patient (1.01%) and 11 kidney transplant patients (0.44%) were found to be positive for HEV RNA. The HEV isolates from all viremic patients were typed as genotype 3. Four patients developed chronic hepatitis E after transplantation. Three patients were treated with ribavirin; their liver enzymes normalized, and HEV RNA became negative immediately. Sustained virologic response was achieved in all cases. Conclusions. This is the first nationwide survey of HEV infection in Japanese heart and kidney transplant recipients. The prevalence of anti-HEV IgG and HEV RNA in heart and kidney transplant recipients in Japan was lower than that in European countries. Of note, 42% of viremic transplant patients developed chronic hepatitis.

Original language	English
Pages (from-to)	437-444
Number of pages	8
Journal	Transplantation
DOIs	https://doi.org/10.1097/TP.0000000000002801
Publication status	Accepted/In press - 2020

All Science Journal Classification (ASJC) codes

Transplantation

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/TP.0000000000002801

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Owada, Y., Oshiro, Y., Inagaki, Y., Harada, H., Fujiyama, N., Kawagishi, N., Yagisawa, T., Usui, J., Akutsu, N., Itabashi, Y., Saito, K., Watarai, Y., Ichimaru, N., Imamura, R., Kyakuno, M., Ide, K., Shibuya, Y., Okabe, Y., Ono, M., ... Ohkohchi, N. (Accepted/In press). A nationwide survey of hepatitis E virus infection and chronic hepatitis in heart and kidney transplant recipients in Japan. Transplantation, 437-444. https://doi.org/10.1097/TP.0000000000002801

Owada, Y, Oshiro, Y, Inagaki, Y, Harada, H, Fujiyama, N, Kawagishi, N, Yagisawa, T, Usui, J, Akutsu, N, Itabashi, Y, Saito, K, Watarai, Y, Ichimaru, N, Imamura, R, Kyakuno, M, Ide, K, Shibuya, Y, Okabe, Y, Ono, M, Sasaki, K, Shiose, A, Yamagishi, K, Ohnishi, H, Nagashima, S, Takahashi, M, Yuzawa, K, Okamoto, H & Ohkohchi, N 2020, 'A nationwide survey of hepatitis E virus infection and chronic hepatitis in heart and kidney transplant recipients in Japan', Transplantation, pp. 437-444. https://doi.org/10.1097/TP.0000000000002801

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title = "A nationwide survey of hepatitis E virus infection and chronic hepatitis in heart and kidney transplant recipients in Japan",

abstract = "Background: Recently, chronic hepatitis E has been reported in solid organ transplant (SOT) recipients in European countries. Previously, we clarified the prevalence of hepatitis E virus (HEV) infection in Japanese liver transplant recipients and identified 2 chronic hepatitis E patients infected by blood transfusion. However, the rate of HEV infection in recipients of SOTs other than liver in Japan remains unclear, so we conducted a nationwide survey to clarify the prevalence of chronic HEV infection in Japanese heart and kidney transplant recipients. Methods. A total of 99 heart and 2526 kidney transplant recipients in 17 hospitals in Japan were examined for the presence of the IgG class of anti-HEV antibodies as well as for serum HEV RNA. Results: The prevalence of anti-HEV IgG among heart and kidney transplant recipients was 7.07% (7/99) and 4.08% (103/2526), respectively. One heart transplant patient (1.01%) and 11 kidney transplant patients (0.44%) were found to be positive for HEV RNA. The HEV isolates from all viremic patients were typed as genotype 3. Four patients developed chronic hepatitis E after transplantation. Three patients were treated with ribavirin; their liver enzymes normalized, and HEV RNA became negative immediately. Sustained virologic response was achieved in all cases. Conclusions. This is the first nationwide survey of HEV infection in Japanese heart and kidney transplant recipients. The prevalence of anti-HEV IgG and HEV RNA in heart and kidney transplant recipients in Japan was lower than that in European countries. Of note, 42% of viremic transplant patients developed chronic hepatitis.",

author = "Yohei Owada and Yukio Oshiro and Yuki Inagaki and Hiroshi Harada and Nobuhiro Fujiyama and Naoki Kawagishi and Takashi Yagisawa and Joichi Usui and Naotake Akutsu and Yoshihiro Itabashi and Kazuhide Saito and Yoshihiko Watarai and Naotsugu Ichimaru and Ryoichi Imamura and Miyaji Kyakuno and Kentaro Ide and Yuichi Shibuya and Yasuhiro Okabe and Minoru Ono and Konosuke Sasaki and Akira Shiose and Kazumasa Yamagishi and Hiroshi Ohnishi and Shigeo Nagashima and Masaharu Takahashi and Kenji Yuzawa and Hiroaki Okamoto and Nobuhiro Ohkohchi",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 The Author(s).",

year = "2020",

doi = "10.1097/TP.0000000000002801",

language = "English",

pages = "437--444",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - A nationwide survey of hepatitis E virus infection and chronic hepatitis in heart and kidney transplant recipients in Japan

AU - Owada, Yohei

AU - Oshiro, Yukio

AU - Inagaki, Yuki

AU - Harada, Hiroshi

AU - Fujiyama, Nobuhiro

AU - Kawagishi, Naoki

AU - Yagisawa, Takashi

AU - Usui, Joichi

AU - Akutsu, Naotake

AU - Itabashi, Yoshihiro

AU - Saito, Kazuhide

AU - Watarai, Yoshihiko

AU - Ichimaru, Naotsugu

AU - Imamura, Ryoichi

AU - Kyakuno, Miyaji

AU - Ide, Kentaro

AU - Shibuya, Yuichi

AU - Okabe, Yasuhiro

AU - Ono, Minoru

AU - Sasaki, Konosuke

AU - Shiose, Akira

AU - Yamagishi, Kazumasa

AU - Ohnishi, Hiroshi

AU - Nagashima, Shigeo

AU - Takahashi, Masaharu

AU - Yuzawa, Kenji

AU - Okamoto, Hiroaki

AU - Ohkohchi, Nobuhiro

PY - 2020

Y1 - 2020

N2 - Background: Recently, chronic hepatitis E has been reported in solid organ transplant (SOT) recipients in European countries. Previously, we clarified the prevalence of hepatitis E virus (HEV) infection in Japanese liver transplant recipients and identified 2 chronic hepatitis E patients infected by blood transfusion. However, the rate of HEV infection in recipients of SOTs other than liver in Japan remains unclear, so we conducted a nationwide survey to clarify the prevalence of chronic HEV infection in Japanese heart and kidney transplant recipients. Methods. A total of 99 heart and 2526 kidney transplant recipients in 17 hospitals in Japan were examined for the presence of the IgG class of anti-HEV antibodies as well as for serum HEV RNA. Results: The prevalence of anti-HEV IgG among heart and kidney transplant recipients was 7.07% (7/99) and 4.08% (103/2526), respectively. One heart transplant patient (1.01%) and 11 kidney transplant patients (0.44%) were found to be positive for HEV RNA. The HEV isolates from all viremic patients were typed as genotype 3. Four patients developed chronic hepatitis E after transplantation. Three patients were treated with ribavirin; their liver enzymes normalized, and HEV RNA became negative immediately. Sustained virologic response was achieved in all cases. Conclusions. This is the first nationwide survey of HEV infection in Japanese heart and kidney transplant recipients. The prevalence of anti-HEV IgG and HEV RNA in heart and kidney transplant recipients in Japan was lower than that in European countries. Of note, 42% of viremic transplant patients developed chronic hepatitis.

AB - Background: Recently, chronic hepatitis E has been reported in solid organ transplant (SOT) recipients in European countries. Previously, we clarified the prevalence of hepatitis E virus (HEV) infection in Japanese liver transplant recipients and identified 2 chronic hepatitis E patients infected by blood transfusion. However, the rate of HEV infection in recipients of SOTs other than liver in Japan remains unclear, so we conducted a nationwide survey to clarify the prevalence of chronic HEV infection in Japanese heart and kidney transplant recipients. Methods. A total of 99 heart and 2526 kidney transplant recipients in 17 hospitals in Japan were examined for the presence of the IgG class of anti-HEV antibodies as well as for serum HEV RNA. Results: The prevalence of anti-HEV IgG among heart and kidney transplant recipients was 7.07% (7/99) and 4.08% (103/2526), respectively. One heart transplant patient (1.01%) and 11 kidney transplant patients (0.44%) were found to be positive for HEV RNA. The HEV isolates from all viremic patients were typed as genotype 3. Four patients developed chronic hepatitis E after transplantation. Three patients were treated with ribavirin; their liver enzymes normalized, and HEV RNA became negative immediately. Sustained virologic response was achieved in all cases. Conclusions. This is the first nationwide survey of HEV infection in Japanese heart and kidney transplant recipients. The prevalence of anti-HEV IgG and HEV RNA in heart and kidney transplant recipients in Japan was lower than that in European countries. Of note, 42% of viremic transplant patients developed chronic hepatitis.

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DO - 10.1097/TP.0000000000002801

M3 - Article

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AN - SCOPUS:85077545864

SN - 0041-1337

SP - 437

EP - 444

JO - Transplantation

JF - Transplantation

ER -

A nationwide survey of hepatitis E virus infection and chronic hepatitis in heart and kidney transplant recipients in Japan

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