A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

Yusaku Nakabeppu, Daniel Nathans

Research output: Contribution to journalArticle

340 Citations (Scopus)

Abstract

Fos and Jun transcription factors are induced by a variety of extracellular signaling agents. We describe here an unusual member of the Fos family that is also induced, namely, a truncated form of FosB (ΔFosB) missing the C-terminal 101 amino acids of FosB. ΔFosB retains the dimerization and DNA-binding activities of FosB but has lost the ability in transfection assays to activate a promoter with an AP-1 site and to repress the c-fos promoter. Rather, ΔFosB inhibits gene activation by Jun or Jun + Fos and inhibits repression of the c-fos promoter by FosB or c-Fos, presumably by competing with full-length Fos proteins at the steps of dimerization with Jun and binding to DNA. In stimulated cells ΔFosB may act to limit the transcriptional effects of Fos and Jun proteins.

Original languageEnglish
Pages (from-to)751-759
Number of pages9
JournalCell
Volume64
Issue number4
DOIs
Publication statusPublished - Feb 22 1991
Externally publishedYes

Fingerprint

Dimerization
Aptitude
DNA
Transcription Factor AP-1
Transcriptional Activation
Transfection
Assays
Proteins
Transcription Factors
Genes
Chemical activation
Amino Acids

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. / Nakabeppu, Yusaku; Nathans, Daniel.

In: Cell, Vol. 64, No. 4, 22.02.1991, p. 751-759.

Research output: Contribution to journalArticle

@article{4cd08b3df01c40f886821731e5311172,
title = "A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity",
abstract = "Fos and Jun transcription factors are induced by a variety of extracellular signaling agents. We describe here an unusual member of the Fos family that is also induced, namely, a truncated form of FosB (ΔFosB) missing the C-terminal 101 amino acids of FosB. ΔFosB retains the dimerization and DNA-binding activities of FosB but has lost the ability in transfection assays to activate a promoter with an AP-1 site and to repress the c-fos promoter. Rather, ΔFosB inhibits gene activation by Jun or Jun + Fos and inhibits repression of the c-fos promoter by FosB or c-Fos, presumably by competing with full-length Fos proteins at the steps of dimerization with Jun and binding to DNA. In stimulated cells ΔFosB may act to limit the transcriptional effects of Fos and Jun proteins.",
author = "Yusaku Nakabeppu and Daniel Nathans",
year = "1991",
month = "2",
day = "22",
doi = "10.1016/0092-8674(91)90504-R",
language = "English",
volume = "64",
pages = "751--759",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

AU - Nakabeppu, Yusaku

AU - Nathans, Daniel

PY - 1991/2/22

Y1 - 1991/2/22

N2 - Fos and Jun transcription factors are induced by a variety of extracellular signaling agents. We describe here an unusual member of the Fos family that is also induced, namely, a truncated form of FosB (ΔFosB) missing the C-terminal 101 amino acids of FosB. ΔFosB retains the dimerization and DNA-binding activities of FosB but has lost the ability in transfection assays to activate a promoter with an AP-1 site and to repress the c-fos promoter. Rather, ΔFosB inhibits gene activation by Jun or Jun + Fos and inhibits repression of the c-fos promoter by FosB or c-Fos, presumably by competing with full-length Fos proteins at the steps of dimerization with Jun and binding to DNA. In stimulated cells ΔFosB may act to limit the transcriptional effects of Fos and Jun proteins.

AB - Fos and Jun transcription factors are induced by a variety of extracellular signaling agents. We describe here an unusual member of the Fos family that is also induced, namely, a truncated form of FosB (ΔFosB) missing the C-terminal 101 amino acids of FosB. ΔFosB retains the dimerization and DNA-binding activities of FosB but has lost the ability in transfection assays to activate a promoter with an AP-1 site and to repress the c-fos promoter. Rather, ΔFosB inhibits gene activation by Jun or Jun + Fos and inhibits repression of the c-fos promoter by FosB or c-Fos, presumably by competing with full-length Fos proteins at the steps of dimerization with Jun and binding to DNA. In stimulated cells ΔFosB may act to limit the transcriptional effects of Fos and Jun proteins.

UR - http://www.scopus.com/inward/record.url?scp=0026016404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026016404&partnerID=8YFLogxK

U2 - 10.1016/0092-8674(91)90504-R

DO - 10.1016/0092-8674(91)90504-R

M3 - Article

C2 - 1900040

AN - SCOPUS:0026016404

VL - 64

SP - 751

EP - 759

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -