A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

Yusaku Nakabeppu, Daniel Nathans

Research output: Contribution to journalArticlepeer-review

344 Citations (Scopus)

Abstract

Fos and Jun transcription factors are induced by a variety of extracellular signaling agents. We describe here an unusual member of the Fos family that is also induced, namely, a truncated form of FosB (ΔFosB) missing the C-terminal 101 amino acids of FosB. ΔFosB retains the dimerization and DNA-binding activities of FosB but has lost the ability in transfection assays to activate a promoter with an AP-1 site and to repress the c-fos promoter. Rather, ΔFosB inhibits gene activation by Jun or Jun + Fos and inhibits repression of the c-fos promoter by FosB or c-Fos, presumably by competing with full-length Fos proteins at the steps of dimerization with Jun and binding to DNA. In stimulated cells ΔFosB may act to limit the transcriptional effects of Fos and Jun proteins.

Original languageEnglish
Pages (from-to)751-759
Number of pages9
JournalCell
Volume64
Issue number4
DOIs
Publication statusPublished - Feb 22 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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