A 'neural' response with 3-ms latency evoked by loud sound in profoundly deaf patients

Toshihiko Kato, Kimio Shiraishi, Youich Eura, Kensuke Shibata, Toshifumi Sakata, Tetsuo Morizono, Toyoji Soda

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Abstract

A large negative deflection with a latency of 3 ms was observed in the auditory brainstem response (ABR) waveforms of some patients with peripheral profound deafness. This deflection was termed the N3 potential. In this paper, we review patients with the N3 potential and discuss the characteristics of abnomral ABR waveforms. The origin of the N3 potential was also discussed, especially with respect to vestibular evoked potentials. In most of the patients, audiograms showed no response to the maximum output of an audiometer in the high-frequency range and a residual response in the low-frequency range. The N3 potentials were noted at intensities of 80 dB nHL or greater. As the stimulus intensity increased, the amplitude of the potential increased and the latency decreased. A high repetition rate (83.3/s) of the click stimulus influenced the latency and amplitude of the N3 potential. The potential was replicated on retest within less than a month, and had a consistent latency and amplitude over the scalp. The results indicate that the N3 potential is not an electrical artifact but a physiological neural response evoked by a loud sound. The N3 potential is most likely not an auditory evoked response from cochlear or a response from a semicircular canal, because it has a 3-ms latency, a sharp waveform, and is unassociated with vertigo. The results suggest that the N3 potential may be a saccular acoustic response.

Original languageEnglish
Pages (from-to)253-264
Number of pages12
JournalAudiology and Neuro-Otology
Volume3
Issue number4
DOIs
Publication statusPublished - Jul 1 1998

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Otorhinolaryngology
  • Sensory Systems
  • Speech and Hearing

Cite this

Kato, T., Shiraishi, K., Eura, Y., Shibata, K., Sakata, T., Morizono, T., & Soda, T. (1998). A 'neural' response with 3-ms latency evoked by loud sound in profoundly deaf patients. Audiology and Neuro-Otology, 3(4), 253-264. https://doi.org/10.1159/000013797