A neurotoxic dose of methamphetamine induces gene expression of Homer 1a, but not Homer 1b or 1c, in the striatum and nucleus accumbens

Kijiro Hashimoto, Tatsuo Nakahara, Hidetaka Yamada, Makoto Hirano, Toshihide Kuroki, Shigenobu Kanba

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Homer proteins, which regulate the signaling pathway of metabotropic glutamate receptors, may contribute to the glutamatergic modulation of dopamine neurons in the basal ganglia. This study examined whether the induction of Homer 1 genes is or not associated with the methamphetamine-induced dopaminergic neurotoxicity in the discrete brain regions of rats. Basal levels of Homer 1a and 1c mRNAs in the forebrain regions were higher than those in the substantia nigra, whereas Homer 1b mRNA levels were higher in the substantia nigra than those in the forebrain regions examined. A neurotoxic dose (40 mg/kg, i.p.) of methamphetamine increased the mRNA and protein levels of Homer 1a in the striatum and nucleus accumbens, but not in the medial prefrontal cortex or the substantia nigra. Both Homer 1b and 1c mRNAs were not affected in any brain regions examined. These results suggest that the induction of Homer 1a gene may be involved at least in part in the methamphetamine-induced dopaminergic neurotoxicity, possibly through the glutamate-dopaminergic interaction.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalNeurochemistry International
Volume51
Issue number2-4 SPEC. ISS.
DOIs
Publication statusPublished - Jul 1 2007

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Methamphetamine
Nucleus Accumbens
Gene Expression
Substantia Nigra
Messenger RNA
Prosencephalon
Metabotropic Glutamate Receptors
Dopaminergic Neurons
Brain
Homer Scaffolding Proteins
Basal Ganglia
Prefrontal Cortex
Genes
Glutamic Acid

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

A neurotoxic dose of methamphetamine induces gene expression of Homer 1a, but not Homer 1b or 1c, in the striatum and nucleus accumbens. / Hashimoto, Kijiro; Nakahara, Tatsuo; Yamada, Hidetaka; Hirano, Makoto; Kuroki, Toshihide; Kanba, Shigenobu.

In: Neurochemistry International, Vol. 51, No. 2-4 SPEC. ISS., 01.07.2007, p. 227-232.

Research output: Contribution to journalArticle

Hashimoto, Kijiro ; Nakahara, Tatsuo ; Yamada, Hidetaka ; Hirano, Makoto ; Kuroki, Toshihide ; Kanba, Shigenobu. / A neurotoxic dose of methamphetamine induces gene expression of Homer 1a, but not Homer 1b or 1c, in the striatum and nucleus accumbens. In: Neurochemistry International. 2007 ; Vol. 51, No. 2-4 SPEC. ISS. pp. 227-232.
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