A neutral sugar is responsible for serovar specificity of the antigenic determinant of Leptospira interrogans serovar canicola.

H. Kashiwase, Etsuro Ono, R. Yanagawa, Y. Shimizu, H. Kida

Research output: Contribution to journalArticle

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Abstract

To provide information on the chemical structures of antigenic determinants of leptospira, glycolipids of Leptospira interrogans serovar canicola strain Hond Utrecht IV (Ut-IV) and its antigenic variant selected in the presence of a serovar-specific monoclonal antibody were compared physicochemically. Gas-liquid chromatography-mass spectrometry analysis revealed that the glycolipid of Ut-IV contained 6 neutral sugar species; rhamnose, mannose, galactose, glucose, and unknown sugars III and IV, in addition to unknown sugars I and II that had been previously reported. On the other hand, the glycolipid of the variant lacked unknown sugar III, suggesting that this sugar is responsible for the serovar-specific antigenic determinant.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalThe Japanese journal of veterinary research
Volume42
Issue number2
Publication statusPublished - Jan 1 1994
Externally publishedYes

Fingerprint

Leptospira interrogans serovar canicola
Leptospira interrogans
Glycolipids
epitopes
Epitopes
serotypes
glycolipids
sugars
Leptospira
Rhamnose
Mannose
Netherlands
Galactose
Gas Chromatography-Mass Spectrometry
Monoclonal Antibodies
rhamnose
Glucose
mannose
chemical structure
galactose

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

A neutral sugar is responsible for serovar specificity of the antigenic determinant of Leptospira interrogans serovar canicola. / Kashiwase, H.; Ono, Etsuro; Yanagawa, R.; Shimizu, Y.; Kida, H.

In: The Japanese journal of veterinary research, Vol. 42, No. 2, 01.01.1994, p. 103-108.

Research output: Contribution to journalArticle

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