Isoelectric focusing (pH 4.0-5.0) of serum α2HS-glycoprotein on polyacrylamide gels has been found to be a useful tool in population genetics and forensic science. Using this method, we isolated three common types, α2HS 1-1, α2HS 2-1 and α2HS 2-2, and showed that α2HS types are determined by two autosomal codominant alleles, α2HS1 and α2HS2. The method is simple, fast and easy to perform. Results of typing for the two alleles, α2HS1 and α2HS2, are described for a Japanese population sample (n=1003).
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