A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine

Ikki Yonemura, Noriyuki Yasuda, Toshio Kawanami, Takeshi Hanamoto, Hiroshi Furuno, Junji Inanaga

Research output: Contribution to journalArticle


Both (2R,5R)- and (2S,5S)-diethynylpyrrolidines were conveniently synthesized from 3,6-bis(mesyloxy)-1,7-octadiyne in optically pure forms via (R)-1-(4-methoxyphenyl)ethylamine-induced pyrrolidine ring formation, chromatographic separation of the corresponding diastereomers, and cleavage of the benzylic C-N bond.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
Issue number1
Publication statusPublished - Jan 1 2006


All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

Yonemura, I., Yasuda, N., Kawanami, T., Hanamoto, T., Furuno, H., & Inanaga, J. (2006). A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine. Heterocycles, 67(1), 433-436. https://doi.org/10.3987/COM-05-S(T)59