A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine

Ikki Yonemura, Noriyuki Yasuda, Toshio Kawanami, Takeshi Hanamoto, Hiroshi Furuno, Junji Inanaga

Research output: Contribution to journalArticle

Abstract

Both (2R,5R)- and (2S,5S)-diethynylpyrrolidines were conveniently synthesized from 3,6-bis(mesyloxy)-1,7-octadiyne in optically pure forms via (R)-1-(4-methoxyphenyl)ethylamine-induced pyrrolidine ring formation, chromatographic separation of the corresponding diastereomers, and cleavage of the benzylic C-N bond.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalHeterocycles
Volume67
Issue number1
DOIs
Publication statusPublished - Jan 1 2006

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ethylamine
pyrrolidine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

Yonemura, I., Yasuda, N., Kawanami, T., Hanamoto, T., Furuno, H., & Inanaga, J. (2006). A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine. Heterocycles, 67(1), 433-436. https://doi.org/10.3987/COM-05-S(T)59

A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine. / Yonemura, Ikki; Yasuda, Noriyuki; Kawanami, Toshio; Hanamoto, Takeshi; Furuno, Hiroshi; Inanaga, Junji.

In: Heterocycles, Vol. 67, No. 1, 01.01.2006, p. 433-436.

Research output: Contribution to journalArticle

Yonemura, I, Yasuda, N, Kawanami, T, Hanamoto, T, Furuno, H & Inanaga, J 2006, 'A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine', Heterocycles, vol. 67, no. 1, pp. 433-436. https://doi.org/10.3987/COM-05-S(T)59
Yonemura, Ikki ; Yasuda, Noriyuki ; Kawanami, Toshio ; Hanamoto, Takeshi ; Furuno, Hiroshi ; Inanaga, Junji. / A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine. In: Heterocycles. 2006 ; Vol. 67, No. 1. pp. 433-436.
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