TY - JOUR
T1 - A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine
AU - Yonemura, Ikki
AU - Yasuda, Noriyuki
AU - Kawanami, Toshio
AU - Hanamoto, Takeshi
AU - Furuno, Hiroshi
AU - Inanaga, Junji
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Both (2R,5R)- and (2S,5S)-diethynylpyrrolidines were conveniently synthesized from 3,6-bis(mesyloxy)-1,7-octadiyne in optically pure forms via (R)-1-(4-methoxyphenyl)ethylamine-induced pyrrolidine ring formation, chromatographic separation of the corresponding diastereomers, and cleavage of the benzylic C-N bond.
AB - Both (2R,5R)- and (2S,5S)-diethynylpyrrolidines were conveniently synthesized from 3,6-bis(mesyloxy)-1,7-octadiyne in optically pure forms via (R)-1-(4-methoxyphenyl)ethylamine-induced pyrrolidine ring formation, chromatographic separation of the corresponding diastereomers, and cleavage of the benzylic C-N bond.
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U2 - 10.3987/COM-05-S(T)59
DO - 10.3987/COM-05-S(T)59
M3 - Article
AN - SCOPUS:33646864091
SN - 0385-5414
VL - 67
SP - 433
EP - 436
JO - Heterocycles
JF - Heterocycles
IS - 1
ER -