A new application of a peptide library to identify selective interaction between small peptides in an attempt to develop recognition molecules toward protein surfaces

Shigeki Sasaki, Manabu Takagi, Yoshitsugu Tanaka, Minoru Maeda

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Combinatorial technologies with the use of a solid-phase pentapeptide library and the magnetic beads covalently bound with the target nonapeptide (1) were applied to search for recognition peptides toward the target sequence (1) which constitutes an extracellular part of the dopamine D2 receptor. Several pentapeptides have been identified to exhibit high binding affinities toward the target peptide (1) in an aqueous solution.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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