A new application of a peptide library to identify selective interaction between small peptides in an attempt to develop recognition molecules toward protein surfaces

Shigeki Sasaki, Manabu Takagi, Yoshitsugu Tanaka, Minoru Maeda

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Combinatorial technologies with the use of a solid-phase pentapeptide library and the magnetic beads covalently bound with the target nonapeptide (1) were applied to search for recognition peptides toward the target sequence (1) which constitutes an extracellular part of the dopamine D2 receptor. Several pentapeptides have been identified to exhibit high binding affinities toward the target peptide (1) in an aqueous solution.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 1 1996

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Peptide Library
Membrane Proteins
Peptides
Molecules
Dopamine D2 Receptors
Libraries
Technology

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

A new application of a peptide library to identify selective interaction between small peptides in an attempt to develop recognition molecules toward protein surfaces. / Sasaki, Shigeki; Takagi, Manabu; Tanaka, Yoshitsugu; Maeda, Minoru.

In: Tetrahedron Letters, Vol. 37, No. 1, 01.01.1996, p. 85-88.

Research output: Contribution to journalArticle

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