A new ecdysteroid and other constituents from two Dioscorea species

M. Sautour; F. Canon; Tomofumi Miyamoto; A. Dongmo; M. A. Lacaille-Dubois

doi:10.1016/j.bse.2008.03.002

A new ecdysteroid and other constituents from two Dioscorea species

M. Sautour, F. Canon, Tomofumi Miyamoto, A. Dongmo, M. A. Lacaille-Dubois

Pharmaceutical Health Care and Sciences

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Abstract

Phytochemical investigation of the rhizome of Dioscorea dumetorum has led to the isolation by several chromatographic steps on normal and reversed phase silica gel of a new ecdysteroid, (20R)-5β,11α,20-trihydroxyecdysone (1), and two known ecdysteroids, ajugasterone C (2) and herkesterone (3). Their structures were determined by spectroscopic methods including 1D- and 2D-NMR (COSY, TOCSY, HSQC and HMBC). This is the first report on the occurrence of phytoecdysteroids in the Dioscoreaceae family. These compounds were devoid of antifungal activity against three Candida species (Candida albicans, Candida glabrata and Candida tropicalis, MIC > 200 μg/ml).

Original language	English
Pages (from-to)	559-563
Number of pages	5
Journal	Biochemical Systematics and Ecology
Volume	36
Issue number	7
DOIs	https://doi.org/10.1016/j.bse.2008.03.002
Publication status	Published - Jul 2008

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Biochemistry

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10.1016/j.bse.2008.03.002

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abstract = "Phytochemical investigation of the rhizome of Dioscorea dumetorum has led to the isolation by several chromatographic steps on normal and reversed phase silica gel of a new ecdysteroid, (20R)-5β,11α,20-trihydroxyecdysone (1), and two known ecdysteroids, ajugasterone C (2) and herkesterone (3). Their structures were determined by spectroscopic methods including 1D- and 2D-NMR (COSY, TOCSY, HSQC and HMBC). This is the first report on the occurrence of phytoecdysteroids in the Dioscoreaceae family. These compounds were devoid of antifungal activity against three Candida species (Candida albicans, Candida glabrata and Candida tropicalis, MIC > 200 μg/ml).",

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AU - Sautour, M.

AU - Canon, F.

AU - Miyamoto, Tomofumi

AU - Dongmo, A.

AU - Lacaille-Dubois, M. A.

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AB - Phytochemical investigation of the rhizome of Dioscorea dumetorum has led to the isolation by several chromatographic steps on normal and reversed phase silica gel of a new ecdysteroid, (20R)-5β,11α,20-trihydroxyecdysone (1), and two known ecdysteroids, ajugasterone C (2) and herkesterone (3). Their structures were determined by spectroscopic methods including 1D- and 2D-NMR (COSY, TOCSY, HSQC and HMBC). This is the first report on the occurrence of phytoecdysteroids in the Dioscoreaceae family. These compounds were devoid of antifungal activity against three Candida species (Candida albicans, Candida glabrata and Candida tropicalis, MIC > 200 μg/ml).

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A new ecdysteroid and other constituents from two Dioscorea species

Abstract

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