A new entry in catalytic alkynylation of aldehydes and ketones: Dual activation of soft nucleophiles and hard electrophiles by an indium(III) catalyst

Ryo Takita, Yuhei Fukuta, Riichiro Tsuji, Takashi Ohshima, Masakatsu Shibasaki

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Abstract

(Chemical Equation Presented). A new entry in catalytic alkynylation of carbonyl compounds was developed in which dual activation of both soft nucleophiles (terminal alkynes) and hard electrophiles (aldehydes and ketones) is achieved using an indium(III) catalyst. Preliminary mechanistic studies using in situ IR and NMR spectroscopic analysis are also discussed.

Original languageEnglish
Pages (from-to)1363-1366
Number of pages4
JournalOrganic Letters
Volume7
Issue number7
DOIs
Publication statusPublished - Mar 31 2005
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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