A new glucoside with a potent α-glucosidase inhibitory activity from Lycium schweinfurthii

Ahmed Elbermawi, Ahmed F. Halim, El Sayed S. Mansour, Kadria F. Ahmad, Ahmed Ashour, Yhiya Amen, Kuniyoshi Shimizu

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Abstract

A new glucoside, 3-methoxy-4-O-β-D-glucopyranosyl-methyl benzoate, has been isolated from Lycium schweinfurthii along with five known compounds through bioactivity guided fractionation of the total plant methanolic extract towards α-glucosidase inhibitory activity. All the isolated compounds were tested for their inhibitory effect on α-glucosidase enzyme. As a result, four of them showed a potent inhibitory activity and thus constitute a therapeutic approach to decrease postprandial hyperglycemia in diabetic patients.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusPublished - Jan 1 2019

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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