A new glucoside with a potent α-glucosidase inhibitory activity from Lycium schweinfurthii

Ahmed Elbermawi, Ahmed F. Halim, El Sayed S. Mansour, Kadria F. Ahmad, Ahmed Ashour, Yhiya Amen, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

Abstract

A new glucoside, 3-methoxy-4-O-β-D-glucopyranosyl-methyl benzoate, has been isolated from Lycium schweinfurthii along with five known compounds through bioactivity guided fractionation of the total plant methanolic extract towards α-glucosidase inhibitory activity. All the isolated compounds were tested for their inhibitory effect on α-glucosidase enzyme. As a result, four of them showed a potent inhibitory activity and thus constitute a therapeutic approach to decrease postprandial hyperglycemia in diabetic patients.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusPublished - Jan 1 2019

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Lycium
Glucosidases
glucosidases
Glucosides
glucosides
Plant Extracts
benzoates
hyperglycemia
Fractionation
Bioactivity
plant extracts
Hyperglycemia
fractionation
therapeutics
Enzymes
enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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A new glucoside with a potent α-glucosidase inhibitory activity from Lycium schweinfurthii. / Elbermawi, Ahmed; Halim, Ahmed F.; Mansour, El Sayed S.; Ahmad, Kadria F.; Ashour, Ahmed; Amen, Yhiya; Shimizu, Kuniyoshi.

In: Natural Product Research, 01.01.2019.

Research output: Contribution to journalArticle

Elbermawi, Ahmed ; Halim, Ahmed F. ; Mansour, El Sayed S. ; Ahmad, Kadria F. ; Ashour, Ahmed ; Amen, Yhiya ; Shimizu, Kuniyoshi. / A new glucoside with a potent α-glucosidase inhibitory activity from Lycium schweinfurthii. In: Natural Product Research. 2019.
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