A new method to identify dynamic transduction properties of aortic baroreceptors

M. Sugimachi, T. Imaizumi, K. Sunagawa, Yoshitaka Hirooka, Koji Todaka, A. Takeshita, M. Nakamura

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We identified, in 17 α-chloralose-anesthetized rabbits, the dynamic transduction characteristics of the aortic arch baroreceptors using a 'white-noise technique'. We recorded aortic pressure and aortic depressor nerve activity while perturbing pressure by rapid, intermittent ventricular pacing (400 beats/min). Dividing the cross-power spectrum between nerve activity and pressure by the power spectrum of pressure yielded the transfer function. The gain of the transfer function increased threefold as the frequency increased from 0.005 to 5 Hz, suggesting that the baroreceptors responded primarily to dynamic rather than to static changes in pressure. To quantify the nonlinear properties of baroreceptor transduction, we compared measured instantaneous nerve activity with that linearly predicted. We demonstrated that the major nonlinearity was attributable to 'threshold'. The overall baroreceptor transduction properties could be represented by a cascade connection of a linear subsystem followed by a nonlinear subsystem with threshold. The white-noise technique made it possible to identify the unbiased linear properties in a nonlinear system, and thus was very useful in identifying complex biological systems.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume258
Issue number3 27-3
Publication statusPublished - Jan 1 1990

Fingerprint

Pressoreceptors
Pressure
Chloralose
Thoracic Aorta
Arterial Pressure
Rabbits

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Sugimachi, M., Imaizumi, T., Sunagawa, K., Hirooka, Y., Todaka, K., Takeshita, A., & Nakamura, M. (1990). A new method to identify dynamic transduction properties of aortic baroreceptors. American Journal of Physiology - Heart and Circulatory Physiology, 258(3 27-3).

A new method to identify dynamic transduction properties of aortic baroreceptors. / Sugimachi, M.; Imaizumi, T.; Sunagawa, K.; Hirooka, Yoshitaka; Todaka, Koji; Takeshita, A.; Nakamura, M.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 258, No. 3 27-3, 01.01.1990.

Research output: Contribution to journalArticle

Sugimachi, M, Imaizumi, T, Sunagawa, K, Hirooka, Y, Todaka, K, Takeshita, A & Nakamura, M 1990, 'A new method to identify dynamic transduction properties of aortic baroreceptors', American Journal of Physiology - Heart and Circulatory Physiology, vol. 258, no. 3 27-3.
Sugimachi, M. ; Imaizumi, T. ; Sunagawa, K. ; Hirooka, Yoshitaka ; Todaka, Koji ; Takeshita, A. ; Nakamura, M. / A new method to identify dynamic transduction properties of aortic baroreceptors. In: American Journal of Physiology - Heart and Circulatory Physiology. 1990 ; Vol. 258, No. 3 27-3.
@article{ee9ffbc73f794ee4896b7df7626b2186,
title = "A new method to identify dynamic transduction properties of aortic baroreceptors",
abstract = "We identified, in 17 α-chloralose-anesthetized rabbits, the dynamic transduction characteristics of the aortic arch baroreceptors using a 'white-noise technique'. We recorded aortic pressure and aortic depressor nerve activity while perturbing pressure by rapid, intermittent ventricular pacing (400 beats/min). Dividing the cross-power spectrum between nerve activity and pressure by the power spectrum of pressure yielded the transfer function. The gain of the transfer function increased threefold as the frequency increased from 0.005 to 5 Hz, suggesting that the baroreceptors responded primarily to dynamic rather than to static changes in pressure. To quantify the nonlinear properties of baroreceptor transduction, we compared measured instantaneous nerve activity with that linearly predicted. We demonstrated that the major nonlinearity was attributable to 'threshold'. The overall baroreceptor transduction properties could be represented by a cascade connection of a linear subsystem followed by a nonlinear subsystem with threshold. The white-noise technique made it possible to identify the unbiased linear properties in a nonlinear system, and thus was very useful in identifying complex biological systems.",
author = "M. Sugimachi and T. Imaizumi and K. Sunagawa and Yoshitaka Hirooka and Koji Todaka and A. Takeshita and M. Nakamura",
year = "1990",
month = "1",
day = "1",
language = "English",
volume = "258",
journal = "American Journal of Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "3 27-3",

}

TY - JOUR

T1 - A new method to identify dynamic transduction properties of aortic baroreceptors

AU - Sugimachi, M.

AU - Imaizumi, T.

AU - Sunagawa, K.

AU - Hirooka, Yoshitaka

AU - Todaka, Koji

AU - Takeshita, A.

AU - Nakamura, M.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - We identified, in 17 α-chloralose-anesthetized rabbits, the dynamic transduction characteristics of the aortic arch baroreceptors using a 'white-noise technique'. We recorded aortic pressure and aortic depressor nerve activity while perturbing pressure by rapid, intermittent ventricular pacing (400 beats/min). Dividing the cross-power spectrum between nerve activity and pressure by the power spectrum of pressure yielded the transfer function. The gain of the transfer function increased threefold as the frequency increased from 0.005 to 5 Hz, suggesting that the baroreceptors responded primarily to dynamic rather than to static changes in pressure. To quantify the nonlinear properties of baroreceptor transduction, we compared measured instantaneous nerve activity with that linearly predicted. We demonstrated that the major nonlinearity was attributable to 'threshold'. The overall baroreceptor transduction properties could be represented by a cascade connection of a linear subsystem followed by a nonlinear subsystem with threshold. The white-noise technique made it possible to identify the unbiased linear properties in a nonlinear system, and thus was very useful in identifying complex biological systems.

AB - We identified, in 17 α-chloralose-anesthetized rabbits, the dynamic transduction characteristics of the aortic arch baroreceptors using a 'white-noise technique'. We recorded aortic pressure and aortic depressor nerve activity while perturbing pressure by rapid, intermittent ventricular pacing (400 beats/min). Dividing the cross-power spectrum between nerve activity and pressure by the power spectrum of pressure yielded the transfer function. The gain of the transfer function increased threefold as the frequency increased from 0.005 to 5 Hz, suggesting that the baroreceptors responded primarily to dynamic rather than to static changes in pressure. To quantify the nonlinear properties of baroreceptor transduction, we compared measured instantaneous nerve activity with that linearly predicted. We demonstrated that the major nonlinearity was attributable to 'threshold'. The overall baroreceptor transduction properties could be represented by a cascade connection of a linear subsystem followed by a nonlinear subsystem with threshold. The white-noise technique made it possible to identify the unbiased linear properties in a nonlinear system, and thus was very useful in identifying complex biological systems.

UR - http://www.scopus.com/inward/record.url?scp=0025267596&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025267596&partnerID=8YFLogxK

M3 - Article

VL - 258

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6135

IS - 3 27-3

ER -