A new PICTure of nucleolar stress

Akira Suzuki, Ryunosuke Kogo, Kohichi Kawahara, Masato Sasaki, Miki Nishio, Tomohiko Maehama, Takehiko Sasaki, Koshi Mimori, Masaki Mori

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Cell growth demands new protein synthesis, which requires nucleolar ribosomal functions. Ribosome biogenesis consumes a large proportion of the cell's resources and energy, and so is tightly regulated through an intricate signaling network to guarantee fidelity. Thus, events that impair ribosome biogenesis cause nucleolar stress. In response to this stress, several nucleolar ribosomal proteins (RPs) translocate to the nucleoplasm and bind to MDM2. MDM2-mediated ubiquitination and degradation of the tumor suppressor p53 is then blocked, resulting in p53 accumulation and the induction of p53-dependent cell cycle arrest and apoptosis. Nucleolar stress is therefore a quality control surveillance mechanism that monitors the synthesis and assembly of the rRNA and protein components of ribosomes. Although nucleolar stress signaling pathways have been extensively analyzed, critical questions remain about their regulatory mechanisms. For example, how do RPs translocate from the nucleolus to the nucleoplasm to exert their functions, and do these p53-regulating RPs influence the prognosis of human cancer patients? Our laboratory recently identified the nucleolar protein PICT1 as a novel regulator of nucleolar stress. PICT1 sequesters the ribosomal protein RPL11 in the nucleolus, preventing it from binding to MDM2. MDM2 is then free to degrade p53, favoring tumor cell growth. Accordingly, the level of PICT1 in a tumor is becoming a useful prognostic marker for human cancers. This review summarizes the evidence that links nucleolar stress to tumorigenesis, and casts PICT1 as an oncogenic player in human cancer biology.

Original languageEnglish
Pages (from-to)632-637
Number of pages6
JournalCancer Science
Volume103
Issue number4
DOIs
Publication statusPublished - Apr 1 2012

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Ribosomal Proteins
Ribosomes
Neoplasms
Nuclear Proteins
Ubiquitination
Growth
Cell Cycle Checkpoints
Quality Control
Carcinogenesis
Proteins
Apoptosis

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Suzuki, A., Kogo, R., Kawahara, K., Sasaki, M., Nishio, M., Maehama, T., ... Mori, M. (2012). A new PICTure of nucleolar stress. Cancer Science, 103(4), 632-637. https://doi.org/10.1111/j.1349-7006.2012.02219.x

A new PICTure of nucleolar stress. / Suzuki, Akira; Kogo, Ryunosuke; Kawahara, Kohichi; Sasaki, Masato; Nishio, Miki; Maehama, Tomohiko; Sasaki, Takehiko; Mimori, Koshi; Mori, Masaki.

In: Cancer Science, Vol. 103, No. 4, 01.04.2012, p. 632-637.

Research output: Contribution to journalReview article

Suzuki, A, Kogo, R, Kawahara, K, Sasaki, M, Nishio, M, Maehama, T, Sasaki, T, Mimori, K & Mori, M 2012, 'A new PICTure of nucleolar stress', Cancer Science, vol. 103, no. 4, pp. 632-637. https://doi.org/10.1111/j.1349-7006.2012.02219.x
Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, Maehama T et al. A new PICTure of nucleolar stress. Cancer Science. 2012 Apr 1;103(4):632-637. https://doi.org/10.1111/j.1349-7006.2012.02219.x
Suzuki, Akira ; Kogo, Ryunosuke ; Kawahara, Kohichi ; Sasaki, Masato ; Nishio, Miki ; Maehama, Tomohiko ; Sasaki, Takehiko ; Mimori, Koshi ; Mori, Masaki. / A new PICTure of nucleolar stress. In: Cancer Science. 2012 ; Vol. 103, No. 4. pp. 632-637.
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