Abstract
The aims of the present study were to: (i) develop a clinically useful prognostic classification in Asian patients with metastatic renal cell carcinoma (RCC) by combining metastatic features with several pretreatment parameters; and (ii) evaluate the validity of this prognostic classification. Baseline characteristics and outcomes were collected for 361 patients who underwent interferon-α-based therapy between 1995 and 2005. Relationships between overall survival (OS) and potential prognostic factors were assessed using Cox's proportional hazard model. The predictive performance of the model was evaluated using bootstrap resampling procedures and by using an independent dataset obtained from randomly selected institutions. The predictive accuracy was measured using the concordance index (c-index). Four factors were identified as independent prognostic factors: time from initial diagnosis to treatment, anemia, elevated lactate dehydrogenase (LDH), and poor prognostic metastatic group (liver only, bone only, or multiple organ metastases). Each patient was assigned to one of three risk groups: favorable risk (none or one factor; n = 120), in which median OS was 51 months; intermediate risk (two factors; n = 101), in which median OS was 21 months; and poor risk (three or four factors; n = 102), in which median OS was 10 months. The c-index was 0.72 in the original dataset and 0.72 in 500 random bootstrap samples. In the independent dataset for external validation, the c-index was 0.73. Thus, the new prognostic classification is easily applicable for Asian patients with previously untreated metastatic RCC and should be incorporated into patient care, as well as clinical trials performed in Asia.
| Original language | English |
|---|---|
| Pages (from-to) | 1695-1700 |
| Number of pages | 6 |
| Journal | Cancer Science |
| Volume | 103 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2012 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
A new prognostic classification for overall survival in asian patients with previously untreated metastatic renal cell carcinoma. / Shinohara, Nobuo; Nonomura, Katsuya; Abe, Takashige; Maruyama, Satoru; Kamai, Takao; Takahashi, Masayuki; Tatsugami, Katsunori; Yokoi, Shigeaki; Deguchi, Takashi; Kanayama, Hiroomi; Oba, Koji; Naito, Seiji.
In: Cancer Science, Vol. 103, No. 9, 01.09.2012, p. 1695-1700.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A new prognostic classification for overall survival in asian patients with previously untreated metastatic renal cell carcinoma
AU - Shinohara, Nobuo
AU - Nonomura, Katsuya
AU - Abe, Takashige
AU - Maruyama, Satoru
AU - Kamai, Takao
AU - Takahashi, Masayuki
AU - Tatsugami, Katsunori
AU - Yokoi, Shigeaki
AU - Deguchi, Takashi
AU - Kanayama, Hiroomi
AU - Oba, Koji
AU - Naito, Seiji
PY - 2012/9/1
Y1 - 2012/9/1
N2 - The aims of the present study were to: (i) develop a clinically useful prognostic classification in Asian patients with metastatic renal cell carcinoma (RCC) by combining metastatic features with several pretreatment parameters; and (ii) evaluate the validity of this prognostic classification. Baseline characteristics and outcomes were collected for 361 patients who underwent interferon-α-based therapy between 1995 and 2005. Relationships between overall survival (OS) and potential prognostic factors were assessed using Cox's proportional hazard model. The predictive performance of the model was evaluated using bootstrap resampling procedures and by using an independent dataset obtained from randomly selected institutions. The predictive accuracy was measured using the concordance index (c-index). Four factors were identified as independent prognostic factors: time from initial diagnosis to treatment, anemia, elevated lactate dehydrogenase (LDH), and poor prognostic metastatic group (liver only, bone only, or multiple organ metastases). Each patient was assigned to one of three risk groups: favorable risk (none or one factor; n = 120), in which median OS was 51 months; intermediate risk (two factors; n = 101), in which median OS was 21 months; and poor risk (three or four factors; n = 102), in which median OS was 10 months. The c-index was 0.72 in the original dataset and 0.72 in 500 random bootstrap samples. In the independent dataset for external validation, the c-index was 0.73. Thus, the new prognostic classification is easily applicable for Asian patients with previously untreated metastatic RCC and should be incorporated into patient care, as well as clinical trials performed in Asia.
AB - The aims of the present study were to: (i) develop a clinically useful prognostic classification in Asian patients with metastatic renal cell carcinoma (RCC) by combining metastatic features with several pretreatment parameters; and (ii) evaluate the validity of this prognostic classification. Baseline characteristics and outcomes were collected for 361 patients who underwent interferon-α-based therapy between 1995 and 2005. Relationships between overall survival (OS) and potential prognostic factors were assessed using Cox's proportional hazard model. The predictive performance of the model was evaluated using bootstrap resampling procedures and by using an independent dataset obtained from randomly selected institutions. The predictive accuracy was measured using the concordance index (c-index). Four factors were identified as independent prognostic factors: time from initial diagnosis to treatment, anemia, elevated lactate dehydrogenase (LDH), and poor prognostic metastatic group (liver only, bone only, or multiple organ metastases). Each patient was assigned to one of three risk groups: favorable risk (none or one factor; n = 120), in which median OS was 51 months; intermediate risk (two factors; n = 101), in which median OS was 21 months; and poor risk (three or four factors; n = 102), in which median OS was 10 months. The c-index was 0.72 in the original dataset and 0.72 in 500 random bootstrap samples. In the independent dataset for external validation, the c-index was 0.73. Thus, the new prognostic classification is easily applicable for Asian patients with previously untreated metastatic RCC and should be incorporated into patient care, as well as clinical trials performed in Asia.
UR - http://www.scopus.com/inward/record.url?scp=84865793303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865793303&partnerID=8YFLogxK
U2 - 10.1111/j.1349-7006.2012.02351.x
DO - 10.1111/j.1349-7006.2012.02351.x
M3 - Article
C2 - 22642767
AN - SCOPUS:84865793303
VL - 103
SP - 1695
EP - 1700
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 9
ER -