A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions

Fumi Nagatsugi, Natsuko Tokuda, Minoru Maeda, Shigeki Sasaki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have already demonstrated that the oligonucleotides DNA (ODNs) bearing a 2-amino-6-vinylpurine derivative (1) exhibited efficient interstrand cross-linking to cytidine selectively. In this study, a new reactive nucleoside analogue, 2-amino-6-(1-ethylsulfoxy)vinylpurine derivative (7), was designed based on a computational method to achieve high and selective alkylation with cytidine under neutral conditions. It has been demonstrated that the ODN (13) bearing 2-amino-6-(1-ethylsulfoxy)vinylpurine achieved highly selective and efficient cross-linking to cytidine under neutral conditions.

Original languageEnglish
Pages (from-to)2577-2579
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number19
DOIs
Publication statusPublished - Oct 8 2001

Fingerprint

Cytidine
Cross Reactions
Bearings (structural)
Nucleosides
Oligonucleotides
Derivatives
DNA
Alkylation
Computational methods

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions. / Nagatsugi, Fumi; Tokuda, Natsuko; Maeda, Minoru; Sasaki, Shigeki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 19, 08.10.2001, p. 2577-2579.

Research output: Contribution to journalArticle

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