A new steroidal saponin from Dioscorea cayenensis

Marc Sautour, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Alain Dongmo, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


The new 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-20,22-seco-25(R)- furost-5-en-20,22-dione-3-O-α-L-rhamnopyranosyl-(1→4) -α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)] -β-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 μg/ml, respectively), whereas saponins 1-3 were inactive.

Original languageEnglish
Pages (from-to)1353-1355
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number11
Publication statusPublished - Nov 2004

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery


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