A new steroidal saponin from Dioscorea cayenensis

Marc Sautour, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Alain Dongmo, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The new 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-20,22-seco-25(R)- furost-5-en-20,22-dione-3-O-α-L-rhamnopyranosyl-(1→4) -α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)] -β-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 μg/ml, respectively), whereas saponins 1-3 were inactive.

Original languageEnglish
Pages (from-to)1353-1355
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number11
DOIs
Publication statusPublished - Nov 1 2004

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Dioscoreaceae
Dioscorea
Rhizome
Candida
Saponins
Candida albicans
Human Activities
Yeast
Yeasts
Nuclear magnetic resonance
lipoarabinomannan
methyl protodioscin
dioscin
prosapogenin

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Sautour, M., Mitaine-Offer, A. C., Miyamoto, T., Dongmo, A., & Lacaille-Dubois, M. A. (2004). A new steroidal saponin from Dioscorea cayenensis. Chemical and Pharmaceutical Bulletin, 52(11), 1353-1355. https://doi.org/10.1248/cpb.52.1353

A new steroidal saponin from Dioscorea cayenensis. / Sautour, Marc; Mitaine-Offer, Anne Claire; Miyamoto, Tomofumi; Dongmo, Alain; Lacaille-Dubois, Marie Aleth.

In: Chemical and Pharmaceutical Bulletin, Vol. 52, No. 11, 01.11.2004, p. 1353-1355.

Research output: Contribution to journalArticle

Sautour, M, Mitaine-Offer, AC, Miyamoto, T, Dongmo, A & Lacaille-Dubois, MA 2004, 'A new steroidal saponin from Dioscorea cayenensis', Chemical and Pharmaceutical Bulletin, vol. 52, no. 11, pp. 1353-1355. https://doi.org/10.1248/cpb.52.1353
Sautour M, Mitaine-Offer AC, Miyamoto T, Dongmo A, Lacaille-Dubois MA. A new steroidal saponin from Dioscorea cayenensis. Chemical and Pharmaceutical Bulletin. 2004 Nov 1;52(11):1353-1355. https://doi.org/10.1248/cpb.52.1353
Sautour, Marc ; Mitaine-Offer, Anne Claire ; Miyamoto, Tomofumi ; Dongmo, Alain ; Lacaille-Dubois, Marie Aleth. / A new steroidal saponin from Dioscorea cayenensis. In: Chemical and Pharmaceutical Bulletin. 2004 ; Vol. 52, No. 11. pp. 1353-1355.
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