TY - JOUR
T1 - A new steroidal saponin from Dioscorea cayenensis
AU - Sautour, Marc
AU - Mitaine-Offer, Anne Claire
AU - Miyamoto, Tomofumi
AU - Dongmo, Alain
AU - Lacaille-Dubois, Marie Aleth
PY - 2004/11/1
Y1 - 2004/11/1
N2 - The new 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-20,22-seco-25(R)- furost-5-en-20,22-dione-3-O-α-L-rhamnopyranosyl-(1→4) -α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)] -β-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 μg/ml, respectively), whereas saponins 1-3 were inactive.
AB - The new 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-20,22-seco-25(R)- furost-5-en-20,22-dione-3-O-α-L-rhamnopyranosyl-(1→4) -α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)] -β-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 μg/ml, respectively), whereas saponins 1-3 were inactive.
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U2 - 10.1248/cpb.52.1353
DO - 10.1248/cpb.52.1353
M3 - Article
C2 - 15516762
AN - SCOPUS:21644466555
VL - 52
SP - 1353
EP - 1355
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 11
ER -