A new steroidal saponin from Dioscorea cayenensis

Marc Sautour; Anne Claire Mitaine-Offer; Tomofumi Miyamoto; Alain Dongmo; Marie Aleth Lacaille-Dubois

doi:10.1248/cpb.52.1353

A new steroidal saponin from Dioscorea cayenensis

Marc Sautour, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Alain Dongmo, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article

39 Citations (Scopus)

Abstract

The new 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-20,22-seco-25(R)- furost-5-en-20,22-dione-3-O-α-L-rhamnopyranosyl-(1→4) -α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)] -β-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 μg/ml, respectively), whereas saponins 1-3 were inactive.

Original language	English
Pages (from-to)	1353-1355
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	11
DOIs	https://doi.org/10.1248/cpb.52.1353
Publication status	Published - Nov 1 2004

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All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

Cite this

Sautour, M., Mitaine-Offer, A. C., Miyamoto, T., Dongmo, A., & Lacaille-Dubois, M. A. (2004). A new steroidal saponin from Dioscorea cayenensis. Chemical and Pharmaceutical Bulletin, 52(11), 1353-1355. https://doi.org/10.1248/cpb.52.1353

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10.1248/cpb.52.1353