A new strategy based on fluorodeoxyglucose-positron emission tomography for managing liver metastasis from colorectal cancer

Akira Watanabe, Norifumi Harimoto, Kenichiro Araki, Tomoharu Yoshizumi, Kota Arima, Yoichi Yamashita, Hideo Baba, Higuchi Tetsuya, Hiroyuki Kuwano, Ken Shirabe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Prognostic models are needed to manage liver metastasis from colorectal cancer (CRLM). Thus, we developed an algorithm to guide treatment based on the standardized uptake value (SUV) from fluorodeoxyglucose-positron emission tomography (FDG-PET). Methods: We retrospectively evaluated 148 patients who underwent surgery for CRLM, including 107 cases of primary surgery and 41 cases with preoperative chemotherapy before conversion surgery. We evaluated the prognostic value of perioperative SUV among primary surgery cases, as well as the prognostic value of the SUV change ratio after conversion surgery (postchemotherapy/prechemotherapy SUV). Results: In the primary surgery group, recurrence-free survival (RFS) was independently predicted by an SUV of ≥6.04 (P = 0.042) and ≥4 liver metastases (P = 0.003). The combination of an SUV of ≥6.04 and ≥4 liver metastases was strongly associated with poor RFS (P < 0.001). In the conversion surgery group, the SUV change ratio was associated with tumor size change and pathological response. An SUV change ratio of ≥0.293 was associated with shorter RFS (P = 0.006) and independently predicted RFS (P = 0.026). We established a therapeutic algorithm for managing CRLM based on these results. Conclusion: FDG-PET may be useful for predicting recurrence and prognosis in cases of CRLM, and our algorithm may be useful for managing multiple CRLMs.

Original languageEnglish
Pages (from-to)1088-1095
Number of pages8
JournalJournal of Surgical Oncology
Volume118
Issue number7
DOIs
Publication statusPublished - Dec 1 2018

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Positron-Emission Tomography
Colorectal Neoplasms
Neoplasm Metastasis
Liver
Recurrence
Survival
Drug Therapy
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

A new strategy based on fluorodeoxyglucose-positron emission tomography for managing liver metastasis from colorectal cancer. / Watanabe, Akira; Harimoto, Norifumi; Araki, Kenichiro; Yoshizumi, Tomoharu; Arima, Kota; Yamashita, Yoichi; Baba, Hideo; Tetsuya, Higuchi; Kuwano, Hiroyuki; Shirabe, Ken.

In: Journal of Surgical Oncology, Vol. 118, No. 7, 01.12.2018, p. 1088-1095.

Research output: Contribution to journalArticle

Watanabe, A, Harimoto, N, Araki, K, Yoshizumi, T, Arima, K, Yamashita, Y, Baba, H, Tetsuya, H, Kuwano, H & Shirabe, K 2018, 'A new strategy based on fluorodeoxyglucose-positron emission tomography for managing liver metastasis from colorectal cancer', Journal of Surgical Oncology, vol. 118, no. 7, pp. 1088-1095. https://doi.org/10.1002/jso.25250
Watanabe, Akira ; Harimoto, Norifumi ; Araki, Kenichiro ; Yoshizumi, Tomoharu ; Arima, Kota ; Yamashita, Yoichi ; Baba, Hideo ; Tetsuya, Higuchi ; Kuwano, Hiroyuki ; Shirabe, Ken. / A new strategy based on fluorodeoxyglucose-positron emission tomography for managing liver metastasis from colorectal cancer. In: Journal of Surgical Oncology. 2018 ; Vol. 118, No. 7. pp. 1088-1095.
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abstract = "Background: Prognostic models are needed to manage liver metastasis from colorectal cancer (CRLM). Thus, we developed an algorithm to guide treatment based on the standardized uptake value (SUV) from fluorodeoxyglucose-positron emission tomography (FDG-PET). Methods: We retrospectively evaluated 148 patients who underwent surgery for CRLM, including 107 cases of primary surgery and 41 cases with preoperative chemotherapy before conversion surgery. We evaluated the prognostic value of perioperative SUV among primary surgery cases, as well as the prognostic value of the SUV change ratio after conversion surgery (postchemotherapy/prechemotherapy SUV). Results: In the primary surgery group, recurrence-free survival (RFS) was independently predicted by an SUV of ≥6.04 (P = 0.042) and ≥4 liver metastases (P = 0.003). The combination of an SUV of ≥6.04 and ≥4 liver metastases was strongly associated with poor RFS (P < 0.001). In the conversion surgery group, the SUV change ratio was associated with tumor size change and pathological response. An SUV change ratio of ≥0.293 was associated with shorter RFS (P = 0.006) and independently predicted RFS (P = 0.026). We established a therapeutic algorithm for managing CRLM based on these results. Conclusion: FDG-PET may be useful for predicting recurrence and prognosis in cases of CRLM, and our algorithm may be useful for managing multiple CRLMs.",
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AU - Arima, Kota

AU - Yamashita, Yoichi

AU - Baba, Hideo

AU - Tetsuya, Higuchi

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AU - Shirabe, Ken

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