A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement

Katsuhiko Tomooka, Takahiro Takeda, Au Wing Kuen, Takeshi Nakai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An asymmetric synthesis of the chiral β-lactone precursor of the HMG-CoA synthase, inhibitor L-659,699, is described, which involves as the key step an asymmetric [2,3]-Wittig rearrangement to control the stereogenic centers at the ring carbons (C2' and C3').

Original languageEnglish
Pages (from-to)671-674
Number of pages4
JournalHeterocycles
Volume47
Issue number2
Publication statusPublished - Dec 1 1998
Externally publishedYes

Fingerprint

antibiotic 1233A
Hydroxymethylglutaryl-CoA Synthase
Lactones
Carbon

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement. / Tomooka, Katsuhiko; Takeda, Takahiro; Kuen, Au Wing; Nakai, Takeshi.

In: Heterocycles, Vol. 47, No. 2, 01.12.1998, p. 671-674.

Research output: Contribution to journalArticle

Tomooka, Katsuhiko ; Takeda, Takahiro ; Kuen, Au Wing ; Nakai, Takeshi. / A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement. In: Heterocycles. 1998 ; Vol. 47, No. 2. pp. 671-674.
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