A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement

Katsuhiko Tomooka, Takahiro Takeda, Au Wing Kuen, Takeshi Nakai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An asymmetric synthesis of the chiral β-lactone precursor of the HMG-CoA synthase, inhibitor L-659,699, is described, which involves as the key step an asymmetric [2,3]-Wittig rearrangement to control the stereogenic centers at the ring carbons (C2' and C3').

Original languageEnglish
Pages (from-to)671-674
Number of pages4
JournalHeterocycles
Volume47
Issue number2
DOIs
Publication statusPublished - Jan 1 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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