A nitric oxide synthase inhibitor attenuates neuropeptide y - and clonidine- induced feeding in the neonatal chick

T. Bungo, Y. H. Choi, Masataka Shimojo, Y. Masuda, D. M. Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

It is reported that inhibition of nitric oxide (NO) synthase (NOS) decreased food intake in mammalian and avian species. On the other liand, central administration of α3-agonists stimulated. food intake in both species. Similarly, neuropeptide Y (NPY) has the orexigenic effect mediated by α2, receptors. The present study was done to determine whether central injection of NG-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, in the neonatal chick modulates uie increase in food intake induced by NPY- and clonidine (CLON, a. specifie α2-agonist)- induced food intake. Both NPY (2.5 μg)- and CLON (50 ng)-induced food. intake of neona.tal chicks was significantly attenuated by co- administration with the higher doses of L-NAME (0, 0.2, 0.4 and 0.8 mg). Our results suggest that NO may internet with orexigenie systems in modulating food intake in the neonatal chick.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalJournal of Applied Animal Research
Volume17
Issue number2
DOIs
Publication statusPublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

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