Abstract
A highly efficient synthesis of the key intermediate 2 of 1β-methylcarbapenems was accomplished in 10 steps and 30% overall yield starting from commercially available (S)-methyl 3-hydroxy-2-methylpropionate. The explored synthetic scheme features the addition reaction of diketene with a chiral imine as a key diastereoselective step.
Original language | English |
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Pages (from-to) | 6241-6244 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 27 |
Issue number | 51 |
DOIs | |
Publication status | Published - 1986 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry