A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells

Masakazu Abe, Tsuyoshi Sugiura, Miho Takahashi, kotaro ishii, Miyuki Shimoda, Kanemitsu Shirasuna

Research output: Contribution to journalArticle

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Abstract

In this study, we analyzed the effect of the metastasis suppressor CD82/KAI-1, a member of the tetraspanin superfamily, on intercellular adhesion on cancer cells. The newly established invasion assay and the cell aggregation assay revealed that CD82 strengthens E-cadherin-mediated intercellular adhesion. Interestingly, ectopic expression of CD82 stabilized E-cadherin/β-catenin complex formation. Furthermore, CD82 reduced tyrosine phosphorylation of β-catenin on HGF stimulation. Taken together, CD82 may stabilize or strengthen E-cadherin-dependent intercellular adhesion by regulating β-catenin-mediated signal transduction on cancer cells, and consequently, prevent cancer cells from seceding from the primary tumor site.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalCancer Letters
Volume266
Issue number2
DOIs
Publication statusPublished - Aug 8 2008

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Cadherins
Cell Adhesion
Catenins
Neoplasms
Cell Aggregation
Tyrosine
Signal Transduction
Phosphorylation
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells. / Abe, Masakazu; Sugiura, Tsuyoshi; Takahashi, Miho; ishii, kotaro; Shimoda, Miyuki; Shirasuna, Kanemitsu.

In: Cancer Letters, Vol. 266, No. 2, 08.08.2008, p. 163-170.

Research output: Contribution to journalArticle

Abe, Masakazu ; Sugiura, Tsuyoshi ; Takahashi, Miho ; ishii, kotaro ; Shimoda, Miyuki ; Shirasuna, Kanemitsu. / A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells. In: Cancer Letters. 2008 ; Vol. 266, No. 2. pp. 163-170.
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