Abstract
We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.
Original language | English |
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Number of pages | 1 |
Publication status | Published - Dec 1 2006 |
Event | 55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sep 20 2006 → Sep 22 2006 |
Other
Other | 55th Society of Polymer Science Japan Symposium on Macromolecules |
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Country | Japan |
City | Toyama |
Period | 9/20/06 → 9/22/06 |
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All Science Journal Classification (ASJC) codes
- Engineering(all)
Cite this
A novel gene carrier for the therapy of viral infection disease. / Kuramoto, Masanori; Kawamura, Kenji; Asai, Daisuke; Mori, Takeshi; Niidome, Takurou; Shoji, Yoko; Nakashima, Hideki; Katayama, Yoshiki.
2006. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.Research output: Contribution to conference › Paper
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TY - CONF
T1 - A novel gene carrier for the therapy of viral infection disease
AU - Kuramoto, Masanori
AU - Kawamura, Kenji
AU - Asai, Daisuke
AU - Mori, Takeshi
AU - Niidome, Takurou
AU - Shoji, Yoko
AU - Nakashima, Hideki
AU - Katayama, Yoshiki
PY - 2006/12/1
Y1 - 2006/12/1
N2 - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.
AB - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.
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M3 - Paper
AN - SCOPUS:33846144803
ER -