A novel gene carrier for the therapy of viral infection disease

Masanori Kuramoto, Kenji Kawamura, Daisuke Asai, Takeshi Mori, Takurou Niidome, Yoko Shoji, Hideki Nakashima, Yoshiki Katayama

Research output: Contribution to conference › Paper

Abstract

We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006 → Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/06 → 9/22/06

Fingerprint

Peptides
Genes
DNA
Viruses
Polymers
Substrates
Peptide Hydrolases

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Kuramoto, M., Kawamura, K., Asai, D., Mori, T., Niidome, T., Shoji, Y., ... Katayama, Y. (2006). A novel gene carrier for the therapy of viral infection disease. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.

A novel gene carrier for the therapy of viral infection disease. / Kuramoto, Masanori; Kawamura, Kenji; Asai, Daisuke; Mori, Takeshi; Niidome, Takurou; Shoji, Yoko; Nakashima, Hideki; Katayama, Yoshiki.

2006. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.

Research output: Contribution to conference › Paper

Kuramoto, M, Kawamura, K, Asai, D, Mori, T, Niidome, T, Shoji, Y, Nakashima, H & Katayama, Y 2006, 'A novel gene carrier for the therapy of viral infection disease', Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 9/20/06 - 9/22/06.
Kuramoto M, Kawamura K, Asai D, Mori T, Niidome T, Shoji Y et al. A novel gene carrier for the therapy of viral infection disease. 2006. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.
Kuramoto, Masanori ; Kawamura, Kenji ; Asai, Daisuke ; Mori, Takeshi ; Niidome, Takurou ; Shoji, Yoko ; Nakashima, Hideki ; Katayama, Yoshiki. / A novel gene carrier for the therapy of viral infection disease. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.1 p.
@conference{4043182d59214622a0f7506244aab0c4,
title = "A novel gene carrier for the therapy of viral infection disease",
abstract = "We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.",
author = "Masanori Kuramoto and Kenji Kawamura and Daisuke Asai and Takeshi Mori and Takurou Niidome and Yoko Shoji and Hideki Nakashima and Yoshiki Katayama",
year = "2006",
month = "12",
day = "1",
language = "English",
note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - CONF

T1 - A novel gene carrier for the therapy of viral infection disease

AU - Kuramoto, Masanori

AU - Kawamura, Kenji

AU - Asai, Daisuke

AU - Mori, Takeshi

AU - Niidome, Takurou

AU - Shoji, Yoko

AU - Nakashima, Hideki

AU - Katayama, Yoshiki

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

AB - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

UR - http://www.scopus.com/inward/record.url?scp=33846144803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846144803&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846144803

ER -

Access to Document