A novel gene carrier for the therapy of viral infection disease

Masanori Kuramoto; Kenji Kawamura; Daisuke Asai; Takeshi Mori; Takurou Niidome; Yoko Shoji; Hideki Nakashima; Yoshiki Katayama

A novel gene carrier for the therapy of viral infection disease

Masanori Kuramoto, Kenji Kawamura, Daisuke Asai, Takeshi Mori, Takurou Niidome, Yoko Shoji, Hideki Nakashima, Yoshiki Katayama

Materials Science and Engineering, School of Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

Original language	English
Number of pages	1
Publication status	Published - Dec 1 2006
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sep 20 2006 → Sep 22 2006

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country	Japan
City	Toyama
Period	9/20/06 → 9/22/06

All Science Journal Classification (ASJC) codes

Engineering(all)

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A novel gene carrier for the therapy of viral infection disease. / Kuramoto, Masanori; Kawamura, Kenji; Asai, Daisuke; Mori, Takeshi; Niidome, Takurou; Shoji, Yoko; Nakashima, Hideki; Katayama, Yoshiki.

2006. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.

Research output: Contribution to conference › Paper › peer-review

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AU - Kuramoto, Masanori

AU - Kawamura, Kenji

AU - Asai, Daisuke

AU - Mori, Takeshi

AU - Niidome, Takurou

AU - Shoji, Yoko

AU - Nakashima, Hideki

AU - Katayama, Yoshiki

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