A novel gene carrier responding to intracellular signal protein kinase Cα

Riki Toita; Jeong Hun Kang; Yuhua Jiang; Takeshi Mori; Takuro Niidome; Yoshiki Ktayama

A novel gene carrier responding to intracellular signal protein kinase Cα

Riki Toita, Jeong Hun Kang, Yuhua Jiang, Takeshi Mori, Takuro Niidome, Yoshiki Ktayama

Materials Science and Engineering, School of Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

Gene therapy has been expected as a medical approach to treat tumors, inheritable diseases and so on. For gene therapy, effective delivery of gene to the target tissue is vitally important. Previously, we have proposed a novel approach for gene therapy using a drug delivery system responding to cellular signal (D-RECS), especially to protein kinase C (PKC) α. PKCα plays an important role in the differentiation and proliferation of tumor cell. It was known that extraordinary activation of PKCα is seen in many cancers such as breast cancer, melanoma, liver cancer and so on. In this study, PKCα was used as a target protein kinase for D-RECS.

Original language	English
Number of pages	1
Publication status	Published - Dec 1 2006
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sep 20 2006 → Sep 22 2006

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country	Japan
City	Toyama
Period	9/20/06 → 9/22/06

All Science Journal Classification (ASJC) codes

Engineering(all)

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title = "A novel gene carrier responding to intracellular signal protein kinase Cα",

abstract = "Gene therapy has been expected as a medical approach to treat tumors, inheritable diseases and so on. For gene therapy, effective delivery of gene to the target tissue is vitally important. Previously, we have proposed a novel approach for gene therapy using a drug delivery system responding to cellular signal (D-RECS), especially to protein kinase C (PKC) α. PKCα plays an important role in the differentiation and proliferation of tumor cell. It was known that extraordinary activation of PKCα is seen in many cancers such as breast cancer, melanoma, liver cancer and so on. In this study, PKCα was used as a target protein kinase for D-RECS.",

author = "Riki Toita and Kang, {Jeong Hun} and Yuhua Jiang and Takeshi Mori and Takuro Niidome and Yoshiki Ktayama",

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T1 - A novel gene carrier responding to intracellular signal protein kinase Cα

AU - Toita, Riki

AU - Kang, Jeong Hun

AU - Jiang, Yuhua

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Ktayama, Yoshiki

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Gene therapy has been expected as a medical approach to treat tumors, inheritable diseases and so on. For gene therapy, effective delivery of gene to the target tissue is vitally important. Previously, we have proposed a novel approach for gene therapy using a drug delivery system responding to cellular signal (D-RECS), especially to protein kinase C (PKC) α. PKCα plays an important role in the differentiation and proliferation of tumor cell. It was known that extraordinary activation of PKCα is seen in many cancers such as breast cancer, melanoma, liver cancer and so on. In this study, PKCα was used as a target protein kinase for D-RECS.

AB - Gene therapy has been expected as a medical approach to treat tumors, inheritable diseases and so on. For gene therapy, effective delivery of gene to the target tissue is vitally important. Previously, we have proposed a novel approach for gene therapy using a drug delivery system responding to cellular signal (D-RECS), especially to protein kinase C (PKC) α. PKCα plays an important role in the differentiation and proliferation of tumor cell. It was known that extraordinary activation of PKCα is seen in many cancers such as breast cancer, melanoma, liver cancer and so on. In this study, PKCα was used as a target protein kinase for D-RECS.

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T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

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