A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations

Katsunori Aoki, Kenji Suzuki, Takashi Sugano, Tetsuya Tasaka, Kazuhiko Nakahara, Osamu Kuge, Akira Omori, Masataka Kasai

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

We have identified a novel gene, Translin, encoding a protein which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies. The encoded protein, Translin, is a previously undescribed type with no significant similarity to known proteins. In the native form, Translin polypeptides form a multimeric structure which is responsible for its DMA binding activity. Nuclear localization of Translin is limited to lymphoid cell lines, raising the intriguing possibility that nuclear transport of Translin is regulated in a physiologically significant way such that active nuclear transport is associated with the lymphoid specific process known as Ig/TCR gene rearrangement.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalNature genetics
Volume10
Issue number2
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

Fingerprint

Genetic Translocation
Genetic Recombination
Carrier Proteins
Cell Nucleus Active Transport
Genes
Immunoglobulin Genes
Proteins
Gene Rearrangement
Active Biological Transport
Consensus Sequence
Lymphocytes
Cell Line
Peptides
Neoplasms

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. / Aoki, Katsunori; Suzuki, Kenji; Sugano, Takashi; Tasaka, Tetsuya; Nakahara, Kazuhiko; Kuge, Osamu; Omori, Akira; Kasai, Masataka.

In: Nature genetics, Vol. 10, No. 2, 01.01.1995, p. 167-174.

Research output: Contribution to journalArticle

Aoki, K, Suzuki, K, Sugano, T, Tasaka, T, Nakahara, K, Kuge, O, Omori, A & Kasai, M 1995, 'A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations', Nature genetics, vol. 10, no. 2, pp. 167-174. https://doi.org/10.1038/ng0695-167
Aoki, Katsunori ; Suzuki, Kenji ; Sugano, Takashi ; Tasaka, Tetsuya ; Nakahara, Kazuhiko ; Kuge, Osamu ; Omori, Akira ; Kasai, Masataka. / A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. In: Nature genetics. 1995 ; Vol. 10, No. 2. pp. 167-174.
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