A novel hindered macrocyclic tetramine containing two bispidine units. A new type of proton sponge

Yuji Miyahara, Kenta Goto, Takahiko Inazu

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A novel cyclam-like macrocyclic tetramine 1a was synthesized via coupling of bispidine and its bis(α-chloroacetamide) followed by reduction. Strongly basic but encrypted nitrogens of 1a were found to abstract a proton from chloroform to form dichlorocarbene.

Original languageEnglish
Pages (from-to)3097-3099
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number17
DOIs
Publication statusPublished - Apr 23 2001

Fingerprint

tetramethylenedisulfotetramine
Porifera
Chloroform
Protons
Nitrogen
bispidine
chloroacetamide
cyclam
dichlorocarbene

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

A novel hindered macrocyclic tetramine containing two bispidine units. A new type of proton sponge. / Miyahara, Yuji; Goto, Kenta; Inazu, Takahiko.

In: Tetrahedron Letters, Vol. 42, No. 17, 23.04.2001, p. 3097-3099.

Research output: Contribution to journalArticle

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