A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis

Motoko Unoki, Kensuke Kumamoto, Ana I. Robles, Jiang Cheng Shen, Zhi Ming Zheng, Curtis C. Harris

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We identified a novel inhibitor of growth family member 2 (ING2) isoform, ING2b, which shares exon 2 with ING2a, but lacks the N-terminal p53 binding region. Contrary to ING2a, ING2b's promoter has no p53 binding sites. Consistently, activation of p53 led to suppression of ING2a, leaving ING2b unaffected. Through isoform-specific targeting, we showed that ING2a knockdown suppressed cell growth only in the presence of p53, ING2b knockdown had no effect on cell growth, and knockdown of both induced cell cycle arrest and apoptosis independently of p53. ING2a and ING2b have compensatory roles that protect cells from cell cycle arrest and apoptosis and may be involved in development of chemotherapeutic resistance.

Original languageEnglish
Pages (from-to)3868-3874
Number of pages7
JournalFEBS Letters
Volume582
Issue number28
DOIs
Publication statusPublished - Nov 26 2008

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Unoki, M., Kumamoto, K., Robles, A. I., Shen, J. C., Zheng, Z. M., & Harris, C. C. (2008). A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. FEBS Letters, 582(28), 3868-3874. https://doi.org/10.1016/j.febslet.2008.10.024