A novel mass-sensitive sensor based on β-cyclodextrin-anchored bisphenol A-imprinted TiO2 ultrathin layers

Seung Woo Lee, Naoki Takahara, Sergiy Korposh, Do Hyeon Yang, Toyoki Kunitake

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A novel approach to fabricating artificial receptors based on the synergic effect of molecular imprinting and host (β-cyclodextrin)-guest (bisphenol A, BPA) interaction in TiO2 ultrathin films prepared by the gas-phase surface sol-gel process was reported. Quartz crystal microbalance (QCM) electrodes were used to confirm the mass-sensitive change due to BPA incorporation and guest binding into the film with the aim of developing a BPA sensor. The concentration of 1 μM (272 ppb) BPA was successfully measured and the limit of detection was estimated to be 0.1 μM (27.2 ppb) BPA. The affinity of the imprinted film to BPA, which was calculated using a Benesi-Hildebrand plot, was ca. 8 times higher than that of the nonimprinted film. This selective binding feature in principle can be applied to more complex organic compounds.

Original languageEnglish
Pages (from-to)229-236
Number of pages8
JournalSensors and Materials
Issue number4
Publication statusPublished - Aug 26 2011

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Materials Science(all)

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