A novel method for extracting interictal epileptiform discharges in multi-channel MEG: Use of fractional type of blind source separation

Teppei Matsubara, Naruhito Hironaga, Taira Uehara, Hiroshi Chatani, Shozo Tobimatsu, Kuniharu Kishida

Research output: Contribution to journalArticle

Abstract

Objective: Visual inspection of interictal epileptiform discharges (IEDs) in multi-channel MEG requires a time-consuming evaluation process and often leads to inconsistent results due to variability of IED waveforms. Here, we propose a novel extraction method for IEDs using a T/k type of blind source separation (BSST/k). Methods: We applied BSST/k with seven patients with focal epilepsy to test the accuracy of identification of IEDs. We conducted comparisons of the results of BSS components with those obtained by visual inspection in sensor-space analysis. Results: BSST/k provided better signal estimation of IEDs compared with sensor-space analysis. Importantly, BSST/k was able to uncover IEDs that could not be detected by visual inspection. Furthermore, IED components were clearly extracted while preserving spike and wave morphology. Variable IED waveforms were decomposed into one dominant component. Conclusions: BSST/k was able to visualize the spreading signals over multiple channels into a single component from a single epileptogenic zone. BSST/k can be applied to focal epilepsy with a simple parameter setting. Significance: Our novel method was able to highlight IEDs with increased accuracy for identification of IEDs from multi-channel MEG data.

Original languageEnglish
Pages (from-to)425-436
Number of pages12
JournalClinical Neurophysiology
Volume131
Issue number2
DOIs
Publication statusPublished - Feb 2020

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Partial Epilepsy

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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A novel method for extracting interictal epileptiform discharges in multi-channel MEG : Use of fractional type of blind source separation. / Matsubara, Teppei; Hironaga, Naruhito; Uehara, Taira; Chatani, Hiroshi; Tobimatsu, Shozo; Kishida, Kuniharu.

In: Clinical Neurophysiology, Vol. 131, No. 2, 02.2020, p. 425-436.

Research output: Contribution to journalArticle

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