A novel method of preparing amine-modifying C-4' oxidized nucleotide

Mariko Aso, K. Ryuo, M. Kondo, H. Suemune

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel method of preparing C-4' oxidized nucleotide, a monomeric model of an alkali labile lesion (1) has been studied. The C-4' selenated 4a and 4b were found to be effective in preparing 3, a monomeric model of 1, by the reaction with NBS (N-bromosuccinimide). The successive reaction of 3 with amine at room temperature afforded the α,β-unsaturated γ-methylene-γ-lactam (2) in good yield.

Original languageEnglish
Pages (from-to)1384-1386
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume48
Issue number9
DOIs
Publication statusPublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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