A novel method of preparing amine-modifying C-4' oxidized nucleotide

Mariko Aso, K. Ryuo, M. Kondo, H. Suemune

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel method of preparing C-4' oxidized nucleotide, a monomeric model of an alkali labile lesion (1) has been studied. The C-4' selenated 4a and 4b were found to be effective in preparing 3, a monomeric model of 1, by the reaction with NBS (N-bromosuccinimide). The successive reaction of 3 with amine at room temperature afforded the α,β-unsaturated γ-methylene-γ-lactam (2) in good yield.

Original languageEnglish
Pages (from-to)1384-1386
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume48
Issue number9
DOIs
Publication statusPublished - Jan 1 2000

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Bromosuccinimide
Lactams
Alkalies
Amines
Nucleotides
Temperature

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

A novel method of preparing amine-modifying C-4' oxidized nucleotide. / Aso, Mariko; Ryuo, K.; Kondo, M.; Suemune, H.

In: Chemical and Pharmaceutical Bulletin, Vol. 48, No. 9, 01.01.2000, p. 1384-1386.

Research output: Contribution to journalArticle

Aso, Mariko ; Ryuo, K. ; Kondo, M. ; Suemune, H. / A novel method of preparing amine-modifying C-4' oxidized nucleotide. In: Chemical and Pharmaceutical Bulletin. 2000 ; Vol. 48, No. 9. pp. 1384-1386.
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