A novel method of preparing amine-modifying C-4' oxidized nucleotide

M. Aso; K. Ryuo; M. Kondo; H. Suemune

doi:10.1248/cpb.48.1384

A novel method of preparing amine-modifying C-4' oxidized nucleotide

M. Aso, K. Ryuo, M. Kondo, H. Suemune

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A novel method of preparing C-4' oxidized nucleotide, a monomeric model of an alkali labile lesion (1) has been studied. The C-4' selenated 4a and 4b were found to be effective in preparing 3, a monomeric model of 1, by the reaction with NBS (N-bromosuccinimide). The successive reaction of 3 with amine at room temperature afforded the α,β-unsaturated γ-methylene-γ-lactam (2) in good yield.

Original language	English
Pages (from-to)	1384-1386
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	48
Issue number	9
DOIs	https://doi.org/10.1248/cpb.48.1384
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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abstract = "A novel method of preparing C-4' oxidized nucleotide, a monomeric model of an alkali labile lesion (1) has been studied. The C-4' selenated 4a and 4b were found to be effective in preparing 3, a monomeric model of 1, by the reaction with NBS (N-bromosuccinimide). The successive reaction of 3 with amine at room temperature afforded the α,β-unsaturated γ-methylene-γ-lactam (2) in good yield.",

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AU - Kondo, M.

AU - Suemune, H.

PY - 2000

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AB - A novel method of preparing C-4' oxidized nucleotide, a monomeric model of an alkali labile lesion (1) has been studied. The C-4' selenated 4a and 4b were found to be effective in preparing 3, a monomeric model of 1, by the reaction with NBS (N-bromosuccinimide). The successive reaction of 3 with amine at room temperature afforded the α,β-unsaturated γ-methylene-γ-lactam (2) in good yield.

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JO - Chemical and Pharmaceutical Bulletin

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A novel method of preparing amine-modifying C-4' oxidized nucleotide

Abstract

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