A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia

Junichi Kira; Takashi Inuzuka; Isao Hozumi; Hajime Wada; Kaoru Tanaka; Hisashi Gondo; Shuzo Sato; Shoji Tsuji; Takuro Kobayashi

doi:10.1016/S0022-510X(96)05305-1

A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia

Junichi Kira, Takashi Inuzuka, Isao Hozumi, Hajime Wada, Kaoru Tanaka, Hisashi Gondo, Shuzo Sato, Shoji Tsuji, Takuro Kobayashi

Department of Neurogy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM λ monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.

Original language	English
Pages (from-to)	47-52
Number of pages	6
Journal	Journal of the Neurological Sciences
Volume	148
Issue number	1
DOIs	https://doi.org/10.1016/S0022-510X(96)05305-1
Publication status	Published - May 1 1997

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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10.1016/S0022-510X(96)05305-1

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Kira, J., Inuzuka, T., Hozumi, I., Wada, H., Tanaka, K., Gondo, H., Sato, S., Tsuji, S., & Kobayashi, T. (1997). A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia. Journal of the Neurological Sciences, 148(1), 47-52. https://doi.org/10.1016/S0022-510X(96)05305-1

A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia. / Kira, Junichi; Inuzuka, Takashi; Hozumi, Isao et al.
In: Journal of the Neurological Sciences, Vol. 148, No. 1, 01.05.1997, p. 47-52.

Research output: Contribution to journal › Article › peer-review

Kira, J, Inuzuka, T, Hozumi, I, Wada, H, Tanaka, K, Gondo, H, Sato, S, Tsuji, S & Kobayashi, T 1997, 'A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia', Journal of the Neurological Sciences, vol. 148, no. 1, pp. 47-52. https://doi.org/10.1016/S0022-510X(96)05305-1

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title = "A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia",

abstract = "We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM λ monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.",

author = "Junichi Kira and Takashi Inuzuka and Isao Hozumi and Hajime Wada and Kaoru Tanaka and Hisashi Gondo and Shuzo Sato and Shoji Tsuji and Takuro Kobayashi",

note = "Funding Information: This work was supported in part by a Research Grant for Neuroimmunological Diseases from the Ministry of Health and Welfare of Japan, and a Grant from the Ministry of Education, Science, Sports and Culture of Japan. We also wish to thank Dr. S. Kusunoki, Department of Neurology, University of Tokyo, for examining the anti-ganglioside antibodies.",

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T1 - A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia

AU - Kira, Junichi

AU - Inuzuka, Takashi

AU - Hozumi, Isao

AU - Wada, Hajime

AU - Tanaka, Kaoru

AU - Gondo, Hisashi

AU - Sato, Shuzo

AU - Tsuji, Shoji

AU - Kobayashi, Takuro

N1 - Funding Information: This work was supported in part by a Research Grant for Neuroimmunological Diseases from the Ministry of Health and Welfare of Japan, and a Grant from the Ministry of Education, Science, Sports and Culture of Japan. We also wish to thank Dr. S. Kusunoki, Department of Neurology, University of Tokyo, for examining the anti-ganglioside antibodies.

PY - 1997/5/1

Y1 - 1997/5/1

N2 - We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM λ monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.

AB - We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM λ monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.

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A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia

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