A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia

Junichi Kira, Takashi Inuzuka, Isao Hozumi, Hajime Wada, Kaoru Tanaka, Hisashi Gondo, Shuzo Sato, Shoji Tsuji, Takuro Kobayashi

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We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM λ monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalJournal of the Neurological Sciences
Issue number1
Publication statusPublished - May 1 1997


All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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