A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia

Jun-Ichi Kira, Takashi Inuzuka, Isao Hozumi, Hajime Wada, Kaoru Tanaka, Hisashi Gondo, Shuzo Sato, Shoji Tsuji, Takuro Kobayashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM λ monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalJournal of the Neurological Sciences
Volume148
Issue number1
DOIs
Publication statusPublished - May 1 1997

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Waldenstrom Macroglobulinemia
Myelin Basic Protein
Molecular Weight
Monoclonal Antibodies
Polyneuropathies
Myelin Sheath
Immunoblotting
Immunoglobulin M
Cytoplasm
Proteins
Neurons
Antibodies
Serum
Gray Matter

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia. / Kira, Jun-Ichi; Inuzuka, Takashi; Hozumi, Isao; Wada, Hajime; Tanaka, Kaoru; Gondo, Hisashi; Sato, Shuzo; Tsuji, Shoji; Kobayashi, Takuro.

In: Journal of the Neurological Sciences, Vol. 148, No. 1, 01.05.1997, p. 47-52.

Research output: Contribution to journalArticle

Kira, Jun-Ichi ; Inuzuka, Takashi ; Hozumi, Isao ; Wada, Hajime ; Tanaka, Kaoru ; Gondo, Hisashi ; Sato, Shuzo ; Tsuji, Shoji ; Kobayashi, Takuro. / A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia. In: Journal of the Neurological Sciences. 1997 ; Vol. 148, No. 1. pp. 47-52.
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